典型文献
Structural insights into ligand binding and activation of the human thyrotropin-releasing hormone receptor
文献摘要：
Dear Editor,
The thyrotropin-releasing hormone(TRH)is the initial hormone of the hypothalamo-pituitary-thyroid axis(HPT),a signaling cascade required for metabolic homeostasis and development in vertebrates.TRH is a tripeptide hormone(pGlu-His-Pro-NH2)that is synthesized in the hypothalamus and activates thyrotropin-releasing hormone receptor(TRHR),a member of class A G protein-coupled receptor(GPCR).Activated TRHR couples to Gq and activates the phospha-tidylinositol(IP3)-calcium-protein kinase C(PKC)pathway1 that ultimately leads to upregulation of thyroid hormones.
文献关键词：
中图分类号：
作者姓名：
Youwei Xu;Hongmin Cai;Chongzhao You;Xinheng He;Qingning Yuan;Hualiang Jiang;Xi Cheng;Yi Jiang;H.Eric Xu
作者机构：
The CAS Key Laboratory of Receptor Research,Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Shanghai,China;University of Chinese Academy of Sciences,Beijing,China;School of Life Science and Technology,ShanghaiTech University,Shanghai,China;State Key Laboratory of Drug Research and CAS Key Laboratory of Receptor Research,Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Shanghai,China
文献出处：
引用格式：
[1]Youwei Xu;Hongmin Cai;Chongzhao You;Xinheng He;Qingning Yuan;Hualiang Jiang;Xi Cheng;Yi Jiang;H.Eric Xu-.Structural insights into ligand binding and activation of the human thyrotropin-releasing hormone receptor)[J].细胞研究（英文版）,2022(09):855-857
A类：
hypothalamo,tripeptide,pGlu,TRHR,tidylinositol,pathway1
B类：
Structural,insights,into,ligand,binding,activation,human,thyrotropin,releasing,receptor,Dear,Editor,
The,initial,pituitary,thyroid,axis,HPT,signaling,cascade,required,metabolic,homeostasis,development,vertebrates,His,Pro,NH2,that,synthesized,hypothalamus,activates,member,class,protein,coupled,GPCR,Activated,couples,Gq,phospha,IP3,calcium,kinase,PKC,ultimately,leads,upregulation,hormones
AB值：
0.56369
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机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
