典型文献
Chromatin architectural alterations due to null mutation of a major CG methylase in riceFA
文献摘要：
Associations between 3D chromatin architectures and epigenetic modifications have been charac-terized in animals. However, any impact of DNA methylation on chromatin architecture in plants is understudied, which is confined to Arabidopsis thaliana. Because plant species differ in genome size, composition, and overall chromatin packing, it is unclear to what extent findings from A. thaliana hold in other species. Moreover, the incomplete chromatin architectural profiles and the low-resolution high-throughput chromosome conformation capture (Hi-C) data from A. thaliana have hampered characterizing its subtle chro-matin structures and their associations with DNA methylation. We constructed a high-resolution Hi-C interaction map for the null OsMET1-2 (the major CG methyltransferase in rice) mutant (osmet1-2) and isogenic wild-type rice (WT). Chromatin structural changes occurred in osmet1-2, including intra-/inter-chromosomal interactions, compartment transition, and topologically asso-ciated domains (TAD) variations. Our findings provide novel insights into the potential function of DNA methylation in TAD formation in rice and confirmed DNA methylation plays similar essential roles in chromatin packing in A. thaliana and rice.
文献关键词：
中图分类号：
作者姓名：
Jinbin Wang;Xiaochong Li;Qianli Dong;Changping Li;Juzuo Li;Ning Li;Baoxu Ding;Xiaofei Wang;Yanan Yu;Tianya Wang;Zhibin Zhang;Yiyang Yu;Man Lang;Zixian Zeng;Bao Liu;Lei Gong
作者机构：
Key Laboratory of Molecular Epigenetics of the Ministry of Education(MOE),Northeast Normal University,Changchun 130024,China;State Key Laboratory of Plant Genomics and National Center for Plant Gene Research,Institute of Genetics and Developmental Biology,Chinese Academy of Sciences,Beijing 100101,China;Hainan Yazhou Bay Seed Lab,Sanya 572025,China;Department of Biological Science,College of Life Science,Sichuan Normal University,Chengdu 610101,China
文献出处：
引用格式：
[1]Jinbin Wang;Xiaochong Li;Qianli Dong;Changping Li;Juzuo Li;Ning Li;Baoxu Ding;Xiaofei Wang;Yanan Yu;Tianya Wang;Zhibin Zhang;Yiyang Yu;Man Lang;Zixian Zeng;Bao Liu;Lei Gong-.Chromatin architectural alterations due to null mutation of a major CG methylase in riceFA)[J].植物学报（英文版）,2022(12):2396-2410
A类：
methylase,riceFA,OsMET1,osmet1
B类：
Chromatin,architectural,alterations,due,null,mutation,major,CG,Associations,between,chromatin,architectures,epigenetic,modifications,have,been,terized,animals,However,any,impact,methylation,plants,understudied,which,confined,Arabidopsis,thaliana,Because,species,differ,genome,size,composition,overall,packing,unclear,what,extent,findings,from,hold,other,Moreover,incomplete,profiles,low,resolution,high,throughput,chromosome,conformation,capture,Hi,data,hampered,characterizing,its,subtle,structures,their,associations,We,constructed,map,methyltransferase,mutant,isogenic,wild,type,WT,structural,changes,occurred,including,intra,chromosomal,interactions,compartment,transition,topologically,ciated,domains,TAD,variations,Our,provide,novel,insights,into,potential,function,confirmed,plays,similar,essential,roles
AB值：
0.579564
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