Iodoacetic acid(IAA)is an unregulated disinfection byproduct in drinking water and has been shown to exert cytotoxicity,genotoxicity,tumorigenicity,and reproductive and devel-opmental toxicity.However,the effects of IAA on gut microbiota and its metabolism are still unknown,especially the association between gut microbiota and the metabolism and toxicity of IAA.In this study,female and male Sprague-Dawley rats were exposed to IAA at 0 and 16 mg/kg bw/day daily for 8 weeks by oral gavage.Results of 16S rRNA gene se-quencing showed that IAA could alter the diversity,relative abundance and function of gut microbiota in female and male rats.IAA also increased the abundance of genes related to steroid hormone biosynthesis in the gut microbiota of male rats.Moreover,metabolomics profiling revealed that IAA could significantly disturb 6 and 13 metabolites in the feces of female and male rats,respectively.In female rats,the level of androstanediol increased in the IAA treatment group.These results were consistent with our previous findings,where IAA was identified as an androgen disruptor.Additionally,the perturbed gut microbiota and altered metabolites were correlated with each other.The results of this study indicated that IAA could disturb gut microbiota and its metabolism.These changes in gut microbiota and its metabolism were associated with the reproductive and developmental toxicity of IAA.

Yujie Sha;Huan Wu;Yue Guo;Xi Liu;Yan Mo;Qiyuan Yang;Shumao Weei;Kunling Long;Du Lu;Ying Xia;Weiwei Zheng;Zhiheng Su;Xiao Wei

Department of Occupational and Environmental Health,School of Public Health,Guangxi Medical University,Nanning 530021,China;Guangxi Key Laboratory of Bioactive Molecules Research and Evaluation,Pharmaceutical College,Guangxi Medical University,Nanning 530021,China;Key Laboratory of the Public Health Safety,Ministry of Education,Department of Environmental Health,School of Public Health,Fudan University,Shanghai 200032,China;Key Laboratory of Longevity and Aging-related Diseases of Chinese Ministry of Education,Guangxi Medical University,Nanning 530021,China;Guangxi Colleges and Universities Key Laboratory of Prevention and Control of Highly Prevalent Diseases,School of Public Health,Guangxi Medical University,Nanning 530021,China;Guangxi Key Laboratory of Environment and Health Research,Guangxi Medical University,Nanning 530021,China

环境科学学报（英文版）

[1]Yujie Sha;Huan Wu;Yue Guo;Xi Liu;Yan Mo;Qiyuan Yang;Shumao Weei;Kunling Long;Du Lu;Ying Xia;Weiwei Zheng;Zhiheng Su;Xiao Wei-.Effects of iodoacetic acid drinking water disinfection byproduct on the gut microbiota and its metabolism in rats)[J].环境科学学报（英文版）,2022(07):91-104

iodoacetic,Iodoacetic,unregulated,genotoxicity,androstanediol

Effects,acid,drinking,water,disinfection,byproduct,gut,microbiota,its,metabolism,rats,IAA,has,been,shown,exert,cytotoxicity,tumorigenicity,reproductive,However,effects,are,still,unknown,especially,association,between,In,this,study,female,Sprague,Dawley,were,exposed,bw,day,daily,weeks,oral,gavage,Results,16S,rRNA,quencing,showed,that,could,diversity,relative,abundance,function,also,increased,genes,steroid,hormone,biosynthesis,Moreover,metabolomics,profiling,revealed,significantly,disturb,metabolites,feces,respectively,level,treatment,group,These,results,consistent,our,previous,findings,where,was,identified,androgen,disruptor,Additionally,perturbed,altered,correlated,each,other,indicated,changes,associated,developmental

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