典型文献
Post-ingestion conversion of dietary indoles into anticancer agents
文献摘要：
There are health benefits from consuming cruciferous vegetables that release indole-3-carbinol(I3C),but the in vivo transformation of I3C-related indoles remains underinvestigated.Here we detail the post-ingestion conversion of I3C into antitumor agents,2-(indol-3-ylmethyl)-3,3'-diindolylmethane(LTr1)and 3,3'-diindolylmethane(DIM),by conceptualizing and materializing the reaction flux derailing(RFD)approach as a means of unraveling these stepwise transformations to be non-enzymatic but pH-dependent and gut microbe-sensitive.In the upper(or acidic)gastrointestinal tract,LTr1 is generated through Michael addition of 3-methyleneindolium(3MI,derived in situ from I3C)to DIM produced from I3C via the formaldehyde-releasing(major)and CO2-liberating(minor)pathways.In the large intestine,'endogenous'I3C and DIM can form,respectively,from couplings of formaldehyde with one and two molecules of indole(a tryptophan catabolite).Acid-producing gut bacteria such as Lactobacillus acidophilus facilitate the H+-promotable steps.This work updates our understanding of the merits of I3C consumption and identifies LTr1 as a drug candidate.
文献关键词：
中图分类号：
作者姓名：
Li Ping Lin;Dan Liu;Jia Cheng Qian;Liang Wu;Quan Zhao;Ren Xiang Tan
作者机构：
State Key Laboratory of Pharmaceutical Biotechnology,Institute of Functional Biomolecules,Nanjing University,Nanjing 210023,China;State Key Laboratory Cultivation Base for TCM Quality and Efficacy,Nanjing University of Chinese Medicine,Nanjing 210023,China
文献出处：
引用格式：
[1]Li Ping Lin;Dan Liu;Jia Cheng Qian;Liang Wu;Quan Zhao;Ren Xiang Tan-.Post-ingestion conversion of dietary indoles into anticancer agents)[J].国家科学评论（英文版）,2022(04):123-133
A类：
underinvestigated,LTr1,conceptualizing,materializing,derailing,methyleneindolium,3MI,promotable
B类：
Post,ingestion,conversion,dietary,indoles,into,anticancer,agents,There,are,health,benefits,from,consuming,cruciferous,vegetables,that,release,carbinol,I3C,but,vivo,related,remains,Here,we,detail,post,antitumor,ylmethyl,diindolylmethane,DIM,by,reaction,flux,RFD,approach,means,unraveling,these,stepwise,transformations,enzymatic,dependent,gut,microbe,sensitive,In,upper,acidic,gastrointestinal,tract,generated,through,Michael,addition,derived,situ,produced,via,formaldehyde,releasing,major,liberating,minor,pathways,large,intestine,endogenous,respectively,couplings,one,two,molecules,tryptophan,catabolite,Acid,producing,bacteria,such,Lactobacillus,acidophilus,facilitate,H+,steps,This,work,updates,our,understanding,merits,consumption,identifies,drug,candidate
AB值：
0.585653
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