典型文献
Endogenous ceramide phosphoethanolamine modulates circadian rhythm via neural-glial coupling in Drosophila
文献摘要：
While endogenous lipids are known to exhibit rhythmic oscillations,less is known about how specific lipids modulate circadian behavior.Through a series of loss-of-function and gain-of-function experiments on ceramide phosphoethanolamine(CPE)synthase of Drosophila,we demonstrated that pan-glial-specific deficiency in membrane CPE,the structural analog of mammalian sphingomyelin(SM),leads to arrhythmic locomotor behavior and shortens lifespan,while the reverse is true for increasing CPE.Comparative proteomics uncovered dysregulated synaptic glutamate utilization and transport in CPE-deficient flies.An extensive genetic screen was conducted to verify the role of differentially expressed proteins in circadian regulation.Arrhythmic locomotion under cpes1 mutant background was rescued only by restoring endogenous CPE or SM through expressing their respective synthases.Our results underscore the essential role of CPE in maintaining synaptic glutamate homeostasis and modulating circadian behavior in Drosophila.The findings suggest that region-specific elevations of functional membrane lipids can benefit circadian regulation.
文献关键词：
中图分类号：
作者姓名：
Xiupeng Chen;Jie Li;Zhongbao Gao;Yang Yang;Wenqing Kuang;Yue Dong;Gek Huey Chua;Xiahe Huang;Binhua Jiang;He Tian;Yingchun Wang;Xun Huang;Yan Li;Sin Man Lam;Guanghou Shui
作者机构：
State Key Laboratory of Molecular Developmental Biology,Institute of Genetics and Developmental Biology,Chinese Academy of Sciences,Beijing 100101,China;University of Chinese Academy of Sciences,Beijing 100049,China;State Key Laboratory of Brain and Cognitive Science,Institute of Biophysics,Chinese Academy of Sciences,Beijing 100101,China;LipidALL Technologies Company Limited,Changzhou 213022,China
文献出处：
引用格式：
[1]Xiupeng Chen;Jie Li;Zhongbao Gao;Yang Yang;Wenqing Kuang;Yue Dong;Gek Huey Chua;Xiahe Huang;Binhua Jiang;He Tian;Yingchun Wang;Xun Huang;Yan Li;Sin Man Lam;Guanghou Shui-.Endogenous ceramide phosphoethanolamine modulates circadian rhythm via neural-glial coupling in Drosophila)[J].国家科学评论（英文版）,2022(12):98-117
A类：
arrhythmic,Arrhythmic,cpes1
B类：
Endogenous,ceramide,phosphoethanolamine,modulates,circadian,via,neural,glial,coupling,Drosophila,While,endogenous,lipids,are,known,exhibit,oscillations,less,about,how,specific,behavior,Through,series,loss,gain,experiments,CPE,we,demonstrated,that,deficiency,membrane,structural,analog,mammalian,sphingomyelin,SM,leads,locomotor,shortens,lifespan,while,reverse,true,increasing,Comparative,proteomics,uncovered,dysregulated,synaptic,glutamate,utilization,transport,deficient,flies,An,extensive,genetic,screen,was,conducted,verify,role,differentially,expressed,proteins,regulation,locomotion,mutant,background,rescued,only,by,restoring,through,expressing,their,respective,synthases,Our,results,underscore,essential,maintaining,homeostasis,modulating,findings,suggest,region,elevations,functional,can,benefit
AB值：
0.613706
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机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
