典型文献
Scaling dictates the decoder structure
文献摘要：
Despite fluctuations in embryo size within a species,the spatial gene expression pattern and hence the embryonic structure can nonetheless maintain the correct proportion to the embryo size.This is known as the scaling phenomenon.For morphogen-induced patterning of gene expression,the positional infor-mation encoded in the local morphogen concentrations is decoded by the downstream genetic network(the decoder).In this paper,we show that the requirement of scaling sets severe constraints on the geo-metric structure of such a local decoder,which in turn enables deduction of mutants'behavior and extraction of regulation information without going into any molecular details.We demonstrate that the Drosophila gap gene system achieves scaling in the way consistent with our theory-the decoder geometry required by scaling correctly accounts for the observed gap gene expression pattern in nearly all maternal morphogen mutants.Furthermore,the regulation logic and the coding/decoding strategy of the gap gene system can also be revealed from the decoder geometry.Our work provides a general the-oretical framework for a large class of problems where scaling output is achieved by non-scaling inputs and a local decoder,as well as a unified understanding of scaling,mutants'behavior,and gene regulation for the Drosophila gap gene svstem.
文献关键词：
中图分类号：
作者姓名：
Jingxiang Shen;Feng Liu;Chao Tang
作者机构：
Center for Quantitative Biology,Peking University,Beijing 100871,China;School of Physics,Peking University,Beijing 100871,China;Peking-Tsinghua Center for Life Sciences,Peking University,Beijing 100871,China
文献出处：
引用格式：
[1]Jingxiang Shen;Feng Liu;Chao Tang-.Scaling dictates the decoder structure)[J].科学通报（英文版）,2022(14):1486-1495
A类：
nonetheless,svstem
B类：
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AB值：
0.537218
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