典型文献
Effects of co-exposure to lead and manganese on learning and memory deficits
文献摘要：
Lead(Pb)and manganese(Mn)are common neurotoxins.However,individuals are subject to co-exposures in real life,and it is therefore important to study these metals in combina-tion.Weaning Sprague-Dawley rats were given ad libitum access to drinking water solutions containing Pb(100 mg/L),Mn(2.5 mg/mL)or a mixture,and each treatment had its own minocycline(50 mg/(kg·day))supplement group.The results showed a significant difference in spatial memory and induction levels of hippocampal long-term potentiation(LTP)in all exposure groups when compared with controls.The combined-exposure group exhibited the most pronounced effect when compared with each of the single-metal exposure groups.Microglia displayed activation at day 3 after exposure alone or in combination,while astro-cytes showed activation at day 5,accompanied by decreased expression levels of GLAST,GLT-1,and GS.Furthermore,the levels of glutamate in the synaptic cleft increased signifi-cantly.When microglial activation was inhibited by minocycline,the activation of astrocytes and the expression of GLAST,GLT-1,and GS were both reversed.In addition,upon minocy-cline treatment,hippocampal LTP impairment and cognitive injury were significantly al-leviated in each of the exposure groups.These results suggest that combined exposure to Pb and Mn can cause greater effects on cognition and synaptic plasticity when compared to single-metal exposure groups.The reason may involve abnormal activation of microglia leading to excessive regulation of astrocytes,resulting in glutamate reuptake dysfunction in astrocytes and leading to perturbed cognition and synaptic plasticity.
文献关键词：
中图分类号：
作者姓名：
Ruili Guan;Tao Wang;Xiaoru Dong;Kejun Du;Juan Li;Fang Zhao;Jie Xu;Bin Li;Gang Zheng;Xuefeng Shen;Baohua Cao;Jing Wang;Michael Aschner;Mingchao Liu;Rui Chen
作者机构：
Key Laboratory of Environmental Medicine Engineering,Ministry of Education,School of Public Health,Southeast University,Nanjing 210009,China;Department of Occupational&Environmental Health and the Ministry of Education Key Lab of Hazard Assessment and Control in Special Operational Environment,School of Public Health,Fourth Military Medical University,Xi'an 710032,China;Department of Physiology,National Key Discipline of Cell Biology,Fourth Military Medical University,Xi'an 710032,China;School of Nursing,Fourth Military Medical University,Xi'an 710032,China;Department of Molecular Pharmacology,Albert Einstein College of Medicine,Bronx,NY,USA;IM Sechenov First Moscow State Medical University,Moscow,Russia
文献出处：
引用格式：
[1]Ruili Guan;Tao Wang;Xiaoru Dong;Kejun Du;Juan Li;Fang Zhao;Jie Xu;Bin Li;Gang Zheng;Xuefeng Shen;Baohua Cao;Jing Wang;Michael Aschner;Mingchao Liu;Rui Chen-.Effects of co-exposure to lead and manganese on learning and memory deficits)[J].环境科学学报（英文版）,2022(11):65-76
A类：
Weaning,minocy,leviated
B类：
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AB值：
0.503887
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