典型文献
Revealing the Cell Entry Dynamic Mechanism of Single Rabies Virus Particle
文献摘要：
T he rabies virus is a neurotropic virus that causes fatal diseases in humans and animals.Although studying the interactions between a single rabies virus and the cell membrane is necessary for understanding the pathogenesis,the internalization dynamic mechanism of single rabies virus in living cells remains largely elusive.Here,we utilized a novel force tracing technique based on atomic force microscopy(AFM)to record the process of single viral entry into host cell.We revealed that the force of the rabies virus internalization distributed at(65±25)pN,and the time was identified by two peaks with spacings of(237.2±59.1)and(790.3±134.4)ms with the corresponding speed of 0.12 and 0.04μm/s,respectively.Our results provide insight into the effects of viral shape during the endocytosis process.This report will be meaningful for understanding the dynamic mechanism of rabies virus early infection.
文献关键词：
中图分类号：
作者姓名：
LI Siying;PAN Yangang;TENG Honggang;SHAN Yuping;YANG Guocheng;WANG Hongda
作者机构：
School of Chemistry and Life Science,Advanced Institute of Materials Science,Changchun University of Technology,Changchun 130012,P.R.China;State Key Laboratory of Electroanalytical Chemistry,Changchun Institute of Applied Chemistry,Chinese Academy of Sciences,Changchun 130022,P.R.China
文献出处：
引用格式：
[1]LI Siying;PAN Yangang;TENG Honggang;SHAN Yuping;YANG Guocheng;WANG Hongda-.Revealing the Cell Entry Dynamic Mechanism of Single Rabies Virus Particle)[J].高等学校化学研究（英文版）,2022(03):838-842
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B类：
Revealing,Cell,Entry,Dynamic,Mechanism,Single,Rabies,Virus,Particle,rabies,virus,neurotropic,that,causes,fatal,diseases,humans,animals,Although,studying,interactions,between,single,membrane,necessary,understanding,pathogenesis,internalization,dynamic,mechanism,living,cells,remains,largely,elusive,Here,utilized,novel,force,tracing,technique,atomic,microscopy,AFM,record,process,viral,entry,into,host,We,revealed,distributed,pN,was,identified,by,two,peaks,spacings,ms,corresponding,speed,respectively,Our,results,provide,insight,effects,shape,during,endocytosis,This,report,will,meaningful,early,infection
AB值：
0.64619
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