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典型文献
Sum Frequency Spectroscopy Studies on Cell Membrane Fusion Induced by Divalent Cations
文献摘要:
Cell membrane fusion is a fundamen-tal biological process involved in a num-ber of cellular living functions.Re-garding this,divalent cations can in-duce fusion of the lipid bilayers through binding and bridging of divalent cations to the charged lipids,thus leading to the cell membrane fusion.How-ever,the elaborate mechanism of cell membrane fusion induced by divalent cations is still needed to be elucidated.Here,surface/interface sensitive sum frequency generation vibrational spec-troscopy(SFG-VS)and dynamic light scattering(DLS)were applied in this research to study the responses of phospholipid monolayer to the exposure of divalent metal ions i.e.Ca2+and Mg2+.According to the particle size distribution results measured by DLS experi-ments,it was found that Ca2+could induce inter-vesicular fusion while Mg2+could not.An octadecyltrichlorosilane self-assembled monolayer(OTS SAM)-lipid monolayer system was designed to model the cell membrane for the SFG-VS experiment.Ca2+could interact with the lipid PO2-head groups more strongly,resulting in cell membrane fusion more easily,in comparison with Mg2+.No specific interaction between the two metal cations and the C=O groups was observed.However,the C=O orientations changed more after Ca2十-PO2-bind-ing than Mg2+mediation on lipid monolayer.Meanwhile,Ca2+could induce dehydration of the lipids(which should be related to the strong Ca2+-PO2-interaction),leading to the reduced hindrance for cell membrane fusion.
文献关键词:
作者姓名:
Xiao-feng Han;Wen-hua Sun;Shu-jing Wang;Xiao-lin Lu
作者机构:
State Key Laboratory of Bioelectronics,School of Biological Science and Medical Engineering,Na-tional Demonstration Center for Experimental,Biomedical Engineering Education,Southeast University,Nanjing 210096,China
引用格式:
[1]Xiao-feng Han;Wen-hua Sun;Shu-jing Wang;Xiao-lin Lu-.Sum Frequency Spectroscopy Studies on Cell Membrane Fusion Induced by Divalent Cations)[J].化学物理学报(英文版),2022(06):883-892
A类:
garding,Ca2+could,Mg2+could,octadecyltrichlorosilane,Mg2+mediation
B类:
Sum,Frequency,Spectroscopy,Studies,Cell,Membrane,Fusion,Induced,by,Divalent,Cations,membrane,fusion,fundamen,biological,process,involved,num,ber,cellular,living,functions,Re,this,divalent,cations,can,bilayers,through,binding,bridging,charged,lipids,thus,leading,elaborate,mechanism,induced,still,needed,elucidated,Here,surface,interface,sensitive,sum,frequency,generation,vibrational,SFG,VS,dynamic,light,scattering,DLS,were,applied,research,study,responses,phospholipid,monolayer,exposure,metal,Ca2+and,According,particle,size,distribution,results,measured,ments,was,found,that,vesicular,not,An,self,assembled,OTS,SAM,system,designed,model,experiment,PO2,head,groups,more,strongly,resulting,easily,comparison,No,specific,interaction,between,two,observed,However,orientations,changed,after,than,Meanwhile,dehydration,which,should,related,reduced,hindrance
AB值:
0.512749
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