典型文献
Mechanism of Danggui Sini Decoction (当归四逆汤) for Atherosclerosis Obliterans Based on Network Pharmacology and Molecular Docking
文献摘要:
Objective: Based on network pharmacology and molecular docking, we want to explore the pharmacological effects and mechanism of Danggui Sini Decoction in the treatment of lower extremity arteriosclerosis obliterans. Methods: Using TCMSP database to search the main active components of Danggui Sini Decoction (当归四逆汤, DSD) and their related targets, Cytoscape3.8.1 software was used to construct a "component-disease-target" interaction network. Meanwhile, DAVID database was used to enrich the key target genes with GO and KEGG functions. And we used Auto Dock Tools 1.5.6 for molecular docking. Results: A total of 45 candidate active molecules and 250 potential target proteins related to ASO were screened. Key genes such as TNF, IL6, VEGFA, MMP9, IL1B, CCL2, CXCL8, ICAM1, VCAM1, and IL10 are mainly through TNF signaling pathway, HIF-1 signaling pathway, cytokine-cytokine receptor interaction, Toll-like receptor signaling pathway, NF-kappa B signaling pathway, MAPK signaling pathway and other biological pathways exert their effects. The results of molecular docking showed that 5UUI-sesamin, 5UUI-paeoniflorin, 4XCT-sesamin, and 4XCT-sesamin have extremely strong binding ability. Conclusion: Danggui Sini Decoction (当归四逆汤, DSD) can synergistically exert pharmacological effects through multiple components, multiple targets, and multiple pathways. On the basis of regulating immunity and inhibiting smooth muscle proliferation, it can prevent the occurrence and development of ASO.
文献关键词:
中图分类号:
作者姓名:
JI Xiao-rui;FAN Kai-fang;LI Xiao-liang;ZHANG Xiao-li;ZHENG Xue-jun;LEI Cai-xia;JIN Qiu-yue;CHEN Kan-ying;WEI Tian-tian;CAO Xue-qiong
作者机构:
Shanxi University of Traditional Chinese Medicine,Taiyuan 030024,China;Affiliated Hospital of Shanxi University of Traditional Chinese Medicine,Taiyuan 030024,China
文献出处:
引用格式:
[1]JI Xiao-rui;FAN Kai-fang;LI Xiao-liang;ZHANG Xiao-li;ZHENG Xue-jun;LEI Cai-xia;JIN Qiu-yue;CHEN Kan-ying;WEI Tian-tian;CAO Xue-qiong-.Mechanism of Danggui Sini Decoction (当归四逆汤) for Atherosclerosis Obliterans Based on Network Pharmacology and Molecular Docking)[J].世界中西医结合杂志(英文),2022(03):28-36
A类:
Sini,Obliterans,5UUI,sesamin,4XCT
B类:
Mechanism,Danggui,Decoction,当归四逆汤,Atherosclerosis,Based,Network,Pharmacology,Molecular,Docking,Objective,network,pharmacology,molecular,docking,want,explore,pharmacological,effects,mechanism,treatment,lower,extremity,arteriosclerosis,obliterans,Methods,Using,TCMSP,database,search,active,components,DSD,their,related,targets,Cytoscape3,software,was,used,construct,disease,interaction,Meanwhile,DAVID,enrich,key,genes,functions,And,Auto,Tools,Results,total,candidate,molecules,potential,proteins,ASO,were,screened,Key,such,IL6,VEGFA,MMP9,IL1B,CCL2,CXCL8,ICAM1,VCAM1,IL10,mainly,through,signaling,HIF,cytokine,receptor,Toll,like,kappa,MAPK,other,biological,pathways,exert,results,showed,that,paeoniflorin,have,extremely,strong,binding,ability,Conclusion,synergistically,multiple,On,basis,regulating,immunity,inhibiting,smooth,muscle,proliferation,prevent,occurrence,development
AB值:
0.504039
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