Subwavelength manipulation of light waves with high precision can enable new and exciting applications in spectroscopy,sensing,and medical imaging.For these applications,miniaturized spectrometers are desirable to enable the on-chip analysis of spectral information.In particular,for imaging-based spectro-scopic sensing mechanisms,the key challenge is to determine the spatial-shift information accurately(i.e.,the spatial displacement introduced by wavelength shift or biological or chemical surface binding),which is similar to the challenge presented by super-resolution imaging.Here,we report a unique"rain-bow"trapping metasurface for on-chip spectrometers and sensors.Combined with super-resolution image processing,the low-setting 4x optical microscope system resolves a displacement of the resonant position within 35 nm on the plasmonic rainbow trapping metasurface with a tiny area as small as 0.002 mm2.This unique feature of the spatial manipulation of efficiently coupled rainbow plasmonic resonances reveals a new platform for miniaturized on-chip spectroscopic analysis with a spectral resolution of 0.032 nm in wavelength shift.Using this low-setting 4x microscope imaging system,we demonstrate a biosensing resolution of 1.92 x 109 exosomes per milliliter for A549-derived exosomes and distinguish between patient samples and healthy controls using exosomal epidermal growth factor receptor(EGFR)expression values,thereby demonstrating a new on-chip sensing system for personalized accurate bio/chemical sensing applications.

Lyu Zhou;Nan Zhang;Chang Chieh Hsu;Matthew Singer;Xie Zeng;Yizheng Li;Haomin Song;Josep Jornet;Yun Wu;Qiaoqiang Gan

Department of Electrical Engineering,The State University of New York at Buffalo,Buffalo,NY 14260,USA;Department of Biomedical Engineering,The State University of New York at Buffalo,Buffalo,NY 14260,USA;Department of Electrical and Computer Engineering,Northeastern University,Boston,MA 02115,USA;Material Science Engineering Program,King Abdullah University of Science and Technology,Thuwal 23955-6900,Saudi Arabia

工程（英文）

[1]Lyu Zhou;Nan Zhang;Chang Chieh Hsu;Matthew Singer;Xie Zeng;Yizheng Li;Haomin Song;Josep Jornet;Yun Wu;Qiaoqiang Gan-.Super-Resolution Displacement Spectroscopic Sensing over a Surface"Rainbow")[J].工程（英文）,2022(10):75-81

Subwavelength,milliliter

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