典型文献
Preparation,Crystal Structure and Fungicidal Activity of N-(5-(benzofuranol-7-oxymethyl)-1,3,4-thiadiazol-2-yl)amide Compounds
文献摘要：
A variety of new N-(5-(benzofuranol-7-oxymethyl)-l,3,4-thiadiazol-2-yl)amide compounds(8a-i)were synthesized through four steps from benzofuranol as raw materials.The crystal structure of compound 8a(C17H21N3O3S,Mr=347.43)was measured by X-ray diffraction,which was classified as monoclinic system,Z=4,V=1742.72(8)?3,De=1.324 Mg/m3,F(000)=736,S=1.03,μ=0.21 mm1,space group P21 with a=9.9177(3),b=8.9519(2),c=19.8679(5)?,the final R=0.035 and wR=0.105 for 3873 observed reflections(I＞2o(7)).The X-ray structure presented N(3)-H(3)…N(2)and C(6)-H(6)…O(3)intermolecular hydrogen bonds,which acted as an important role in stabilizing the crystal structure.Additionally,preliminary biological assay on compound 8a showed good fungicidal activity in vivo,with the inhibition of 75％against Pseudoperonospora cu-bensis at 200 mg/L.
文献关键词：
中图分类号：
作者姓名：
WANG Chun-Nong;ZENG Tai-Ning;LI Sheng-Nan;LI Wan;LI Long-Fei;CAO Fei;YANG Zi-Hui
作者机构：
College of Pharmaceutical Sciences,Key Laboratory of Analytical Science and Technology of Hebei Province,Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of Ministry of Education,Hebei University,Baoding 071002,China;Shan Dong Jinhuahai Biotechnology Co.,Ltd Jinan 251400,China
文献出处：
引用格式：
[1]WANG Chun-Nong;ZENG Tai-Ning;LI Sheng-Nan;LI Wan;LI Long-Fei;CAO Fei;YANG Zi-Hui-.Preparation,Crystal Structure and Fungicidal Activity of N-(5-(benzofuranol-7-oxymethyl)-1,3,4-thiadiazol-2-yl)amide Compounds)[J].结构化学,2022(03):211-217
A类：
Fungicidal,benzofuranol,oxymethyl,thiadiazol,C17H21N3O3S,bensis
B类：
Preparation,Crystal,Structure,Activity,amide,Compounds,variety,new,compounds,8a,were,synthesized,through,four,steps,from,raw,materials,crystal,structure,Mr,was,measured,by,ray,diffraction,which,classified,monoclinic,system,De,Mg,mm1,space,group,P21,final,wR,observed,reflections,2o,presented,intermolecular,hydrogen,bonds,acted,important,role,stabilizing,Additionally,preliminary,biological,assay,showed,good,fungicidal,activity,vivo,inhibition,against,Pseudoperonospora
AB值：
0.572849
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机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
