典型文献
Artematrovirenolides A-D and Artematrolides S-Z,Sesquiterpenoid Dimers with Cytotoxicity against Three Hepatoma Cell Lines from Artemisia atrovirens
文献摘要：
Inspired by the intriguing structures and remarkable activities of sesquiterpenoid dimers,12 new sesquiterpenoid dimers,arte-matrovirenolides A-D (1-4) and artematrolides S-Z (8-12),were isolated from the EtOAc fraction of Artemisia atrovirens through a bioactivity-guided approach.Their structures were elucidated by comprehensive spectroscopic data and absolute config-uration was assigned based on single crystal X-ray diffraction data and ECD calculations.Structurally,all compounds are presumably formed via[4+2]cycloaddition involving three connecting model.Compounds 1-4 are four novel hetero-dimeric[4+2]Diels-Alder adducts dimerized from a rotundane-type unit and a guaiane-type monomer,and compounds 5-12 are eight new homo-dimeric[4+2]adducts derived from two guaianolide moieties.A putative biosynthetic pathway for compounds 1-4 was also proposed.Compounds 4,6,7,and 10 demonstrated moderate cytotoxicity against HepG2,SMMC-7721,and Huh7 cell lines with ICs0 values ranging from 9.3 to 62.3 μmol/L.Interestingly,compounds 5 and 11 manifested cytotoxicity with IC50 values of 13.6 and 12.8(HepG2),18.5 and 13.1 (SMMC-7721),and 16.5 and 19.4 μmol/L (Huh7),respectively,which were equivalent to the positive control,sorafenib.This investigation suggests that compounds 5 and 11 might be considered as potent antihepatoma candidates and de-serve further structural modification and mechanism study.
文献关键词：
中图分类号：
作者姓名：
Li-Hua Su;Tian-Ze Li;Yun-Bao Ma;Chang-An Geng;Xiao-Yan Huang;Xin Zhang;Zhen Gao;Ji-Jun Chen
作者机构：
State Key Laboratory of Phytochemistry and Plant Resources in West China,Yunnan Key Laboratory of Natural Medicinal Chemistry,Kunming Institute of Botany,Chinese Academy of Sciences,Kunming,Yunnan 650201,China;University of Chinese Academy of Sciences,Beijing 100049,China
文献出处：
引用格式：
[1]Li-Hua Su;Tian-Ze Li;Yun-Bao Ma;Chang-An Geng;Xiao-Yan Huang;Xin Zhang;Zhen Gao;Ji-Jun Chen-.Artematrovirenolides A-D and Artematrolides S-Z,Sesquiterpenoid Dimers with Cytotoxicity against Three Hepatoma Cell Lines from Artemisia atrovirens)[J].中国化学（英文版）,2022(01):104-114
A类：
Artematrovirenolides,Artematrolides,Sesquiterpenoid,Dimers,Hepatoma,atrovirens,matrovirenolides,artematrolides,EtOAc,rotundane,guaianolide,antihepatoma
B类：
Cytotoxicity,against,Three,Cell,Lines,from,Artemisia,Inspired,by,intriguing,structures,remarkable,activities,sesquiterpenoid,dimers,new,were,isolated,through,bioactivity,guided,approach,Their,elucidated,comprehensive,spectroscopic,data,absolute,config,uration,was,assigned,single,crystal,ray,diffraction,ECD,calculations,Structurally,compounds,are,presumably,formed,via,4+2,cycloaddition,involving,three,connecting,model,Compounds,four,novel,hetero,dimeric,Diels,Alder,adducts,dimerized,type,unit,guaiane,monomer,eight,homo,derived,two,moieties,putative,biosynthetic,pathway,also,proposed,demonstrated,moderate,cytotoxicity,HepG2,SMMC,Huh7,cell,lines,ICs0,values,ranging,Interestingly,manifested,IC50,respectively,which,equivalent,positive,control,sorafenib,This,investigation,suggests,that,might,be,considered,potent,candidates,serve,further,structural,modification,mechanism,study
AB值：
0.598397
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