In this review, we offer a concise overview of liver cancer epidemiology in China and worldwide from the official databases of GLOBOCAN 2020 and the National Cancer Registry in China. We also summarized the evidence for the main risk factors associated with liver cancer risk and discuss strategies implemented in China to control the liver cancer burden. Overall, liver cancer was the sixth most commonly diagnosed cancer and the third leading cause of cancer-related death worldwide in 2020. Although China contributed to nearly half of cases across the world alone, the incidence and mortality rates of liver cancer presented a declining trend owing to the persistent efforts from the governments at all levels. The current liver cancer burden in China still faces an arduous challenge due to the relatively large population base as well as the substantially low survival rate (12.1％). To better control the liver cancer burden with the lowest cost, specific measures should be conducted by reducing exposure to established risk factors such as hepatitis B infection and aflatoxin. The promotion of surveillance is also an important method to prolong the survival of liver cancer. This review will provide basic information for future direction on the control of liver cancer burden.

Qianru Li;Maomao Cao;Lin Lei;Fan Yang;He Li;Xinxin Yan;Siyi He;Shaoli Zhang;Yi Teng;Changfa Xia;Wanqing Chen

Office of Cancer Screening,National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100021,China;Department of Cancer Prevention and Control,Shenzhen Center for Chronic Disease Control,Shenzhen 518020,China

中国癌症研究（英文版）

[1]Qianru Li;Maomao Cao;Lin Lei;Fan Yang;He Li;Xinxin Yan;Siyi He;Shaoli Zhang;Yi Teng;Changfa Xia;Wanqing Chen-.Burden of liver cancer: From epidemiology to prevention)[J].中国癌症研究（英文版）,2022(06):554-566

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