Background::Although Th17 cells and regulatory T cells play critical roles in autoimmune hepatitis, the balance between them in acute and chronic immune hepatitis is not well-studied. The objective of this study was to explore the role of Th17/Treg balance in autoimmune hepatitis.Methods::Thirty female Wistar rats were randomly divided into the following three groups: acute model (AC), chronic model (CC), and healthy control (HC). Aspartate aminotransferase, alanine aminotransferase, and bilirubin levels were measured. Peripheral blood interleukin (IL)-17, IL-6, IL-10, and transforming growth factor-β cytokine levels were also assessed. Flow cytometry was used to detect changes in the Th17 cell and Treg cell frequency, and the Th17/Treg ratio was calculated.Results::The frequency of Th17 cells and Treg cells were both increased ( p < 0.05) and the Th17/Treg ratio was higher in the AC group compared with those in the HC group ( p < 0.05). Th17 cell levels were significantly lower and Treg cell levels were significantly higher in the CC group, compared with those in the AC group ( p < 0.05). In addition, the Th17/Treg ratio was lower in the CC group compared with that in the HC group ( p < 0.05). Conclusion::The Th17/Treg ratio was increased in the acute immune liver injury model and decreased in the chronic liver injury model. Th17/Treg imbalance may play a critical role in liver injury occurrence and development.

α-galcer;autoimmune hepatitis;ConA;Th17 cells;Treg cells

Xue Miao;Feng Junshuai;Yang Aimin;Gao Liping;Peng Xuebin;Jiang Ni;Mao Xiaorong

Department of Rheumatology and Immunology, The First Hospital of Lanzhou University, Lanzhou, China;Department of Infectious Diseases, Gansu Provincial Hospital, Lanzhou, China;Department of Medicine & Therapeutics, The Chinese University of Hong Kong, Hong Kong, China;Department of Infectious Diseases, The First Hospital of Lanzhou University, Lanzhou, China

风湿病与自身免疫（英文）

[1]Xue Miao;Feng Junshuai;Yang Aimin;Gao Liping;Peng Xuebin;Jiang Ni;Mao Xiaorong-.Th17/Treg balance and factors related to autoimmune hepatitis)[J].风湿病与自身免疫（英文）,2022(04):221-229

galcer

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