典型文献
Screening for early-onset neonatal sepsis on the Kaiser Permanente sepsis risk calculator could reduce neonatal antibiotic usage by two-thirds
文献摘要：
Importance::Effective screening strategies for early-onset neonatal sepsis (EONS) have the potential to reduce high volume parenteral antibiotics (PAb) usage in neonates.Objective::To compare management decisions for EONS, between CG149 National Institute for Health and Care Excellence (NICE) guidelines and those projected through the virtual application of the Kaiser Permanente sepsis risk calculator (SRC) in a level 2 neonatal unit at a district general hospital (DGH).Methods::Hospital records were reviewed for maternal and neonatal risk factors for EONS, neonatal clinical examination findings, and microbial culture results for all neonates born at ≥34 weeks’ gestation between February and July 2019, who were (1) managed according to CG149-NICE guidelines or (2) received PAb within 72 h following birth at a DGH in Winchester, UK. SRC projections were obtained using its virtual risk estimator.Results::Sixty infants received PAb within the first 72 h of birth during the study period. Of these, 19 (31.7%) met SRC criteria for antibiotics; 20 (33.3%) met the criteria for enhanced observations and none had culture-proven sepsis. Based on SRC projections, neonates with '≥1 NICE clinical indicator and ≥1 risk factor’ were most likely to have a sepsis risk score (SRS) >3. Birth below 37 weeks’ gestation (risk ratio [RR] = 2.31, 95% confidence interval [CI]: 1.02–5.22) and prolonged rupture of membranes (RR = 3.14, 95% CI: 1.16–8.48) increased the risk of an SRS >3.Interpretation::Screening for EONS on the SRC could potentially reduce PAb usage by 68% in term and near-term neonates in level 2 neonatal units.
文献关键词：
Early onset neonatal sepsis;Kaiser Permanente sepsis risk calculator;NICE guidelines;Parenteral antibiotics
中图分类号：
作者姓名：
Fernandes Michelle;Winckworth Lucinda;Lee Lyrille;Akram Madiha;Struthers Simon
作者机构：
The Department of Neonatal Medicine and the Neonatal Intensive Care Unit, Princess Anne Hospital, University Hospitals Southampton NHS Foundation Trust, Southampton, UK;The MRC Lifecourse Epidemiology Centre and Human Development and Health Academic Unit, Faculty of Medicine, University of Southampton, Southampton, UK;Nuffield Department of Women’s and Reproductive Health, John Radcliffe Hospital, University of Oxford, Oxford, UK;Department of Pediatrics, Royal Hampshire County Hospital, Winchester, UK
文献出处：
引用格式：
[1]Fernandes Michelle;Winckworth Lucinda;Lee Lyrille;Akram Madiha;Struthers Simon-.Screening for early-onset neonatal sepsis on the Kaiser Permanente sepsis risk calculator could reduce neonatal antibiotic usage by two-thirds)[J].儿科学研究（英文）,2022(03):171-178
A类：
EONS,PAb,CG149,DGH,Winchester
B类：
Screening,early,onset,neonatal,sepsis,Kaiser,Permanente,risk,calculator,could,reduce,usage,by,two,thirds,Importance,Effective,screening,strategies,have,high,volume,parenteral,antibiotics,neonates,Objective,To,compare,management,decisions,between,National,Institute,Health,Care,Excellence,NICE,guidelines,those,projected,through,virtual,application,SRC,level,district,general,hospital,Methods,Hospital,records,were,reviewed,maternal,factors,clinical,examination,findings,microbial,culture,results,born,weeks,gestation,February,July,who,managed,according,received,within,following,birth,UK,projections,obtained,using,estimator,Results,Sixty,infants,first,during,study,period,Of,these,met,criteria,enhanced,observations,none,had,proven,Based,indicator,most,likely,score,SRS,Birth,below,ratio,RR,confidence,interval,prolonged,rupture,membranes,increased,Interpretation,potentially,term,near,units,Early,Parenteral
AB值：
0.474818
相似文献
机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
