典型文献
Molecular targeted therapies for pediatric atypical teratoid/rhabdoid tumors
文献摘要：
Atypical teratoid/rhabdoid tumors (AT/RTs) are lethal central nervous system tumors, which are primarily diagnosed in infants. Current treatments for AT/RTs include surgery, radiotherapy, and chemotherapy; these treatments have poor prognoses and challenging side effects. The pivotal genetic event in AT/RT pathogenesis comprises the inactivation of
SMARCB1 or
SMARCA4. Recent epigenetic studies have demonstrated mutual and subtype-specific epigenetic derangements that drive tumorigenesis; the exploitation of these potential targets might improve the dismal treatment outcomes of AT/RTs. This review aims to summarize the literature concerning targeted molecular therapies for pediatric AT/RTs.
文献关键词：
Atypical teratoid/rhabdoid tumors;SMARCB1;SMARCA4;SWI/SNF complex;Targeted molecular therapy
中图分类号：
作者姓名：
Zhang Chang;Li Hao
作者机构：
Department of Neurosurgery, Children’s Hospital of Fudan University, Shanghai, China
文献出处：
引用格式：
[1]Zhang Chang;Li Hao-.Molecular targeted therapies for pediatric atypical teratoid/rhabdoid tumors)[J].儿科学研究（英文）,2022(02):111-122
A类：
RTs,derangements
B类：
Molecular,targeted,therapies,pediatric,atypical,teratoid,rhabdoid,tumors,Atypical,AT,are,lethal,central,nervous,system,which,primarily,diagnosed,infants,Current,treatments,include,surgery,radiotherapy,chemotherapy,these,have,poor,prognoses,challenging,side,effects,pivotal,event,pathogenesis,comprises,inactivation,SMARCB1,SMARCA4,Recent,epigenetic,studies,demonstrated,mutual,subtype,specific,that,drive,tumorigenesis,exploitation,potential,targets,might,improve,dismal,outcomes,This,review,aims,summarize,literature,concerning,molecular,SWI,SNF,complex,Targeted
AB值：
0.598815
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机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
