典型文献
Current status and perspectives of conversion therapy for advanced gastric cancer
文献摘要：
The concept and strategy of advanced gastric cancer treatment have gradually undergone profound changes with the in-depth understanding of the biology and heterogeneous characteristics of gastric cancer.Moreover,the development and application of new anticancer drugs,including chemotherapy drugs,molecularly targeted drugs and immunotherapy drugs for advanced gastric cancer are reported.The connotation of conversion therapy refers to the unresectable or borderline resectable tumors for surgical technical and/or oncological reasons,after active and effective chemotherapy and other comprehensive treatment,the primary gastric lesions can be reduced to a lower stage,while the metastatic lesions can be effectively controlled,to achieve R0 resection and improve the long-term survival rate.Current promising research results of conversion therapy are mostly from single-arm phase Ⅱ clinical studies with small samples or retrospective studies.Conversion therapy still faces many challenges,including limited diagnostic and assessment methods,insufficient evidence of highly effective treatment regimens,difficulty in clarifying surgical indications,etc.Therefore,the integrated conversion therapy for advanced gastric cancer needs to be carried out with the close cooperation of a multidisciplinary team.Prospective,multi-center randomized controlled trial studies should be conducted in the future,and precision medicine such as molecular biology should be combined to provide better anticancer drug regimens and higher-level clinical evidence for conversion therapy of advanced gastric cancer.
文献关键词：
中图分类号：
作者姓名：
Heli Yang;Ke Ji;Jiafu Ji
作者机构：
Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing),Center of Gastrointestinal Cancer,Peking University Cancer Hospital&Institute,Beijing 100142,China
文献出处：
引用格式：
[1]Heli Yang;Ke Ji;Jiafu Ji-.Current status and perspectives of conversion therapy for advanced gastric cancer)[J].中国癌症研究（英文版）,2022(02):109-114
A类：
B类：
Current,status,perspectives,conversion,advanced,gastric,concept,strategy,treatment,have,gradually,undergone,profound,changes,depth,understanding,biology,heterogeneous,characteristics,Moreover,development,application,new,anticancer,drugs,including,chemotherapy,molecularly,targeted,immunotherapy,are,reported,connotation,refers,unresectable,borderline,tumors,surgical,technical,oncological,reasons,after,active,comprehensive,primary,lesions,reduced,lower,stage,while,metastatic,effectively,controlled,achieve,R0,resection,improve,long,term,survival,promising,research,results,mostly,from,single,arm,phase,clinical,studies,small,samples,retrospective,Conversion,still,faces,many,challenges,limited,diagnostic,assessment,methods,insufficient,evidence,highly,regimens,difficulty,clarifying,indications,etc,Therefore,integrated,needs,carried,out,close,cooperation,multidisciplinary,team,Prospective,center,randomized,trial,should,conducted,future,precision,medicine,such,combined,provide,better,higher,level
AB值：
0.582864
相似文献
机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
