典型文献
Fungal Translocation Marker in People Living with HIV Needing Treatment for Onychomycosis: A Protocol for the Prospective Pilot Study
文献摘要：
Increased microbial translocation and chronic immune activation are two critical problems for people living with HIV (PLWH) in the antiretroviral therapy (ART) era. Compared with numerous studies on bacterial microbiomic communities, there are only a limited number of studies focusing on fungal microbiomic composition and products in PLWH. This study protocol is used to evaluate the changes in bacterial and fungal microbiome populations induced by terbinafine treatment, which is an antifungal agent widely used amongst PLWH. Twenty-two PLWH on a stable ART regimen for more than six months, who require treatment for onychomycosis, will be recruited. The participants will be followed-up for a 12-week treatment period (oral terbinafine 250 mg daily) and another 12-weeks of terbinafine discontinuation. Plasma and fecal samples will be collected before and after terbinafine treatment, and for 12weeks after the discontinuation of terbinafine. Plasma gut injury and microbial translocation biomarker assays, in addition to testing for gut microbiome composition, will be undertaken. With this pilot study, we will perform formal sample size calculations and test study feasibility for a possible full-scale study.
文献关键词：
HIV;Fungal translocation;Microbial translocation;Onychomycosis;Terbinafine
中图分类号：
作者姓名：
Chen Yaling;Ouyang Jing;Isnard Stéphane;Costiniuk Cecilia T.;Yan Jiangyu;Zhou Xin;Routy Jean-Pierre;Chen Yaokai
作者机构：
Chongqing Public Health Medical Center, Chongqing 400030, China;Infectious Diseases and Immunity in Global Health Program, Research Institute, McGill University Health Centre, Montréal, QC, Canada;Chronic Viral Illness Service, McGill University Health Centre, Montréal, QC, Canada;Division of Hematology, McGill University Health Centre, Montréal, QC, Canada
文献出处：
引用格式：
[1]Chen Yaling;Ouyang Jing;Isnard Stéphane;Costiniuk Cecilia T.;Yan Jiangyu;Zhou Xin;Routy Jean-Pierre;Chen Yaokai-.Fungal Translocation Marker in People Living with HIV Needing Treatment for Onychomycosis: A Protocol for the Prospective Pilot Study)[J].感染性疾病和免疫（英文）,2022(02):122-124
A类：
Needing,Onychomycosis,microbiomic,12weeks
B类：
Fungal,Translocation,Marker,People,Living,HIV,Treatment,Protocol,Prospective,Pilot,Study,Increased,microbial,translocation,chronic,immune,activation,two,critical,problems,people,living,PLWH,antiretroviral,therapy,ART,Compared,numerous,studies,bacterial,communities,there,only,limited,number,focusing,composition,products,This,study,protocol,used,evaluate,changes,microbiome,populations,induced,by,terbinafine,treatment,which,antifungal,agent,widely,amongst,Twenty,stable,regimen,more,than,six,months,who,require,onychomycosis,will,recruited,participants,followed,up,period,oral,daily,another,discontinuation,Plasma,fecal,samples,collected,before,after,gut,injury,biomarker,assays,addition,testing,undertaken,With,this,pilot,perform,formal,size,calculations,feasibility,possible,full,scale,Microbial,Terbinafine
AB值：
0.551272
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