典型文献
Safety and feasibility of same day discharge after per oral endoscopic pyloromyotomy in refractory gastroparesis: a pilot study
文献摘要：
Background::Gastroparesis is a debilitating medical condition with limited treatment options. Gastric per-oral pyloromyotomy (G-POEM) has emerged as a promising treatment option with remarkable short-term clinical success shown in multiple studies. While the post-procedure protocol is not standardized across many centers, the majority of the centers observes these patients in the hospital after the procedure for monitoring. In this single-center prospective study, we evaluated the safety and feasibility of same day discharge after the G-POEM procedure.Methods::All the patients with refractory gastroparesis undergoing G-POEM from October 2019 to March 2020 were enrolled. A total of 25 patients were enrolled in the procedure. Based on the pre-defined criteria, patients were either discharged on the same day after the procedure or admitted to the hospital for further observation. The patient and procedure-related data were extracted from the chart review. Univariate analysis was performed (chi-squared test) on categorical variables after organizing categorical variables as numeric counts or percentages. The student
t test was performed on continuous variables after reporting as mean and standard deviation. For analysis with a smaller sample size, Fisher exact and Mann–Whitney tests were used.
Results::A total of 25 patients were enrolled. The technical success of G-POEM was 100% and clinical success was 80% (20/25) at 1-month follow-up. Of the 25 patients, 9 patients (36%) were discharged on the same day according to the procedure from the recovery unit. Of the remaining 16 patients who were admitted to the hospital post-procedure, 10 (40%) were admitted due to procedure-related causes while other admissions were either pre-planned or due to social reasons. The average Charlson comorbidity index was lower in the same day discharge group (
P < 0.05). The number of patients requiring double myotomy was higher in the same day discharge group (
P < 0.05). The overall complication rate of G-POEM in the study cohort was 12% (3/25) with all complications being mild without any severe adverse events.
Conclusion::G-POEM is a safe and effective method of treatment for refractory GP with higher clinical success in short-term follow-up. The same day discharge after G-POEM is safe and feasible in >50% of patients with close periprocedural monitoring.
文献关键词：
G-POEM;Pyloromyotomy;Gastroparesis;Gastric per-oral pyloromyotomy
中图分类号：
作者姓名：
Shah Rushikesh;Chen Huimin;Calderon Lucie F.;Gooden Tonia;Mubashir Maryam;Rashid Shazia;Raza Syed Musa;Derise Allison;Mccurdy Grace;Sanders Brenna;Keilin Steve;Cai Qiang
作者机构：
Division of Digestive Diseases, Emory University School of Medicine, Atlanta, GA, USA;Division of Gastroenterology and Hepatology, Shanghai Insititute of Digestive Disease, Renji Hospital, Shanghai JiaoTong University School of Medicine, Shanghai 200127, China;Division of Gastroenterology and Hepatology, Louisiana State University, Shreveport, LA, USA
文献出处：
引用格式：
[1]Shah Rushikesh;Chen Huimin;Calderon Lucie F.;Gooden Tonia;Mubashir Maryam;Rashid Shazia;Raza Syed Musa;Derise Allison;Mccurdy Grace;Sanders Brenna;Keilin Steve;Cai Qiang-.Safety and feasibility of same day discharge after per oral endoscopic pyloromyotomy in refractory gastroparesis: a pilot study)[J].中华医学杂志（英文版）,2022(12):1432-1437
A类：
pyloromyotomy,Gastroparesis,Pyloromyotomy
B类：
Safety,feasibility,same,day,after,oral,endoscopic,refractory,gastroparesis,pilot,study,Background,debilitating,medical,condition,limited,treatment,options,Gastric,POEM,has,emerged,promising,remarkable,short,term,clinical,success,shown,multiple,studies,While,post,procedure,protocol,not,standardized,across,many,centers,majority,observes,these,patients,hospital,monitoring,In,this,single,prospective,evaluated,safety,Methods,All,undergoing,from,October,March,were,enrolled,total,Based,pre,defined,criteria,either,discharged,admitted,further,observation,related,data,extracted,chart,review,Univariate,analysis,was,performed,chi,squared,categorical,variables,organizing,numeric,counts,percentages,student,continuous,reporting,mean,deviation,For,smaller,sample,size,Fisher,exact,Mann,Whitney,tests,used,Results,technical,month,follow,Of,according,recovery,unit,remaining,who,due,causes,while,other,admissions,planned,social,reasons,average,Charlson,comorbidity,lower,group,number,requiring,double,higher,overall,rate,cohort,complications,being,mild,without,severe,adverse,events,Conclusion,effective,method,GP,feasible,close,periprocedural
AB值：
0.448169
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