典型文献
Granulation process analysis technologies and potential applications in traditional Chinese medicine
文献摘要：
Pharmaceutical production is changing from batch production to continuous production, during which granulation is one of the most important unit operations. The quality of mass-produced products is traditionally guaranteed by conducting off-line testing, which cannot meet the demand of continuous production for real-time monitoring of critical process parameters and critical quality attributes (CQAs) of the pharmaceutical granulation technology. Since the U.S. Food and Drug Administration proposed process analytical technology (PAT) in 2004, many PAT tools have been developed to monitor the granulation process and provide information regarding the granulation operation conditions and endpoint determination. In this article, we review the recent research and application of two PAT modes in the granulation process, namely, single CQA and multi-CQA PAT, with the aim to provide references for comprehensively improving the technological level of the pharmaceutical granulation process. Furthermore, the potential applications in traditional Chinese Medicine are discussed.
文献关键词：
中图分类号：
作者姓名：
Tongcan Cui;Yizhe Hou;Huimin Feng;Sijun Wu;Wenlong Li;Zheng Li
作者机构：
College of Pharmaceutical Engineering of Traditional Chinese Medicine,Tianjin University of Traditional Chinese Medicine,Tianjin,China;State Key Laboratory of Component-Based Chinese Medicine,Tianjin University of Traditional Chinese Medicine,Tianjin,China
文献出处：
引用格式：
[1]Tongcan Cui;Yizhe Hou;Huimin Feng;Sijun Wu;Wenlong Li;Zheng Li-.Granulation process analysis technologies and potential applications in traditional Chinese medicine)[J].针灸和草药（英文）,2022(01):9-24
A类：
B类：
Granulation,process,analysis,technologies,potential,applications,Chinese,medicine,Pharmaceutical,production,changing,from,batch,continuous,during,which,granulation,one,most,important,unit,operations,quality,mass,produced,products,traditionally,guaranteed,by,conducting,off,line,testing,cannot,meet,demand,real,monitoring,critical,parameters,attributes,CQAs,pharmaceutical,technology,Since,Food,Drug,Administration,proposed,analytical,PAT,many,tools,have,been,developed,provide,information,regarding,conditions,endpoint,determination,In,this,article,we,review,recent,research,two,modes,namely,single,multi,aim,references,comprehensively,improving,technological,level,Furthermore,Medicine,are,discussed
AB值：
0.595773
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