Erianin inhibits oral cancer cell growth, migration, and invasion via the Nrf2/HO-1/GPX4 pathway|Xiu-Yun Tian;Rui Han;Qing-Yang Huang;Mei-Yun Zhou;Bin Luo;Xin-Ru Chen;Jin-Cheng Xu|Bengbu Medical College,Anhui Engineering Technology Research Center of Biochemical Pharmaceuticals,Bengbu 233030,Anhui,China - 期刊导航|首站-论文投稿智能助手|论文发表|论文智能投稿|期刊自助发表推荐|杂志社快速发表|查同导刊-域田数据官方网站

典型文献

Erianin inhibits oral cancer cell growth, migration, and invasion via the Nrf2/HO-1/GPX4 pathway

文献摘要：

Objective: To evaluate the effect of erianin on the viability, migration, and invasion of KB cells and elucidate its underlying mechanisms. Methods: Cell Counting Kit-8, colony formation, wound healing, and Transwell assays were used to determine the proliferation, migration, and invasion of oral cancer KB cells. Furthermore, malondialdehyde (MDA) and glutathione (GSH) levels were determined. Fluorescent probes were used to detect changes in intracellular reactive oxygen species and iron ions. Additionally, the expressions of ferroptosis-related proteins, NF-E2-related factor 2 (Nrf2), ferritin heavy chain 1 (FTH1), heme oxygenase 1 (HO-1), and glutathione peroxidase 4 (GPX4) were analyzed by Western blotting assays. Results: Erianin induced ferroptosis and inhibited the proliferation, migration, and invasion of KB cells. Moreover, erianin decreased GSH level, increased MDA level, elevated intracellular ROS and Fe2+ contents, and downregulated the expression of the ferroptosis-related proteins Nrf2, HO-1, GPX4, and FTH1 in KB cells. These effects of erianin were effectively reversed by a ferroptosis inhibitor, ferrostatin-1. Conclusions: Erianin inhibits the proliferation, migration, and invasion of oral cancer cells and induces ferroptosis via the Nrf2/HO-1/GPX4 signaling pathway. Therefore, erianin may be a potential candidate for the treatment of oral cancer.

文献关键词：

中图分类号：

[1] 医药、卫生（R） / 药学（R9） / 药理学（R96） / 实验药理学（R965）

[2] 医药、卫生（R） / 基础医学（R3） / 病理学（R36） / 病理过程（R364）

[3] 医药、卫生（R） / 中国医学（R2） / 中药学（R28） / 中药药理学（R285） / 中药实验药理（R285.5）

作者姓名：

Xiu-Yun Tian;Rui Han;Qing-Yang Huang;Mei-Yun Zhou;Bin Luo;Xin-Ru Chen;Jin-Cheng Xu

作者机构：

Department of Stomatology,the First Affiliated Hospital of Bengbu Medical College,Bengbu 233000,Anhui,China;Bengbu Medical College,Anhui Engineering Technology Research Center of Biochemical Pharmaceuticals,Bengbu 233030,Anhui,China

文献出处：

亚太热带生物医学杂志（英文版）

引用格式：

[1]Xiu-Yun Tian;Rui Han;Qing-Yang Huang;Mei-Yun Zhou;Bin Luo;Xin-Ru Chen;Jin-Cheng Xu-.Erianin inhibits oral cancer cell growth, migration, and invasion via the Nrf2/HO-1/GPX4 pathway)[J].亚太热带生物医学杂志（英文版）,2022(10):437-445

A类：

Erianin,erianin

B类：

inhibits,oral,cancer,growth,migration,invasion,Nrf2,HO,GPX4,pathway,Objective,To,evaluate,viability,KB,cells,elucidate,underlying,mechanisms,Methods,Cell,Counting,Kit,colony,formation,wound,healing,Transwell,assays,were,used,proliferation,Furthermore,malondialdehyde,glutathione,GSH,levels,determined,Fluorescent,probes,detect,changes,intracellular,reactive,species,iron,Additionally,expressions,ferroptosis,related,proteins,E2,ferritin,heavy,chain,FTH1,heme,oxygenase,peroxidase,analyzed,by,blotting,Results,induced,inhibited,Moreover,decreased,increased,elevated,ROS,Fe2+,contents,downregulated,These,effects,effectively,reversed,inhibitor,ferrostatin,Conclusions,induces,signaling,Therefore,may,potential,candidate,treatment

AB值：

0.476324

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