典型文献
Enhancing pharmaceutical potential and oral bioavailability of Allium cepa nanosuspension in male albino rats using response surface methodology
文献摘要：
Objective: To enhance the pharmaceutical potential and oral bioavailability of quercetin contents of Allium cepa peel extract by novel nanosuspension technology.Methods: Nanoprecipitation approach was successfully used for the formulation of nanosuspension. To obtain pharmaceutical-grade nanosuspension with minimum particle size and polydispersity index, sodium lauryl sulphate was selected as a stabilizer. Important formulation parameters were statistically optimized by the response surface methodology approach. The optimized nanosuspension was subjected to stability and in vitro dissolution testing and characterized by scanning electron microscopy, atomic force microscopy, Fourier transform infrared spectroscopy, and zeta sizer. To evaluate the preeminence of nanosuspension over coarse suspension, comparative bioavailability studies were carried out in male albino rats. The pharmaceutical potential of developed nanosuspension was evaluated by antioxidant, antimicrobial, and toxicity studies. Results: The optimized nanosuspension showed an average particle size of 275.5 nm with a polydispersity index and zeta potential value of 0.415 and ?48.8 mV, respectively. Atomic force microscopy revealed that the average particle size of nanosuspension was below 100 nm. The formulated nanosuspension showed better stability under refrigerated conditions. Nanosuspension showed an improved dissolution rate and a 2.14-fold greater plasma concentration of quercetin than coarse suspension. Moreover, the formulated nanosuspension exhibited enhanced antioxidant and antimicrobial potential and was non-toxic. Conclusions: Optimization of nanosuspension effectively improves the pharmaceutical potential and oral bioavailability of Allium cepa extract.
文献关键词：
中图分类号：
作者姓名：
Fatiqa Zafar;Nazish Jahan;Shaukat Ali;Saba Jamil;Riaz Hussain;Saba Aslam
作者机构：
Department of Chemistry,University of Sahiwal,Sahiwal,Pakistan;Department of Chemistry,University of Agriculture,Faisalabad,Pakistan;Department of Chemistry,University of Okara,Okara,Pakistan;Govt.Graduate College for Women,Sargodha Road,Faisalabad,Pakistan
文献出处：
引用格式：
[1]Fatiqa Zafar;Nazish Jahan;Shaukat Ali;Saba Jamil;Riaz Hussain;Saba Aslam-.Enhancing pharmaceutical potential and oral bioavailability of Allium cepa nanosuspension in male albino rats using response surface methodology)[J].亚太热带生物医学杂志（英文版）,2022(01):26-38
A类：
nanosuspension,sizer,preeminence,refrigerated,Nanosuspension
B类：
Enhancing,pharmaceutical,potential,oral,bioavailability,Allium,cepa,male,albino,rats,using,response,surface,methodology,Objective,To,quercetin,contents,peel,extract,by,novel,technology,Methods,Nanoprecipitation,approach,was,successfully,used,formulation,obtain,grade,minimum,particle,polydispersity,sodium,lauryl,sulphate,selected,stabilizer,Important,parameters,were,statistically,optimized,subjected,stability,vitro,dissolution,testing,characterized,scanning,electron,microscopy,atomic,force,Fourier,transform,infrared,spectroscopy,zeta,coarse,comparative,studies,carried,out,developed,evaluated,antioxidant,antimicrobial,toxicity,Results,showed,average,value,mV,respectively,Atomic,revealed,that,below,formulated,better,under,conditions,improved,fold,greater,plasma,concentration,than,Moreover,exhibited,enhanced,Conclusions,Optimization,effectively,improves
AB值：
0.444955
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