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Non-vitamin K antagonist oral anticoagulants for COVID-19 thrombosis
文献摘要：
Thrombotic complications appear to be a major predictor of death in COVID-19 patients, and multiple studies have shown that anticoagulants can help to improve the outcome. The Food and Drug Administration's acceptance of non-vitamin K antagonist oral anticoagulants (NOACs) has sparked much excitement about their potential as a replacement for existing oral anticoagulants. NOACs target a single clotting factor, often activated factor X or thrombin, and involve the coagulation factor Xa inhibitors including apixaban, edoxaban, and rivaroxaban, and the thrombin inhibitor dabigatran. COVID-19 is an infectious disease that causes thrombotic events by inducing a pro-inflammatory and prothrombotic condition. This article provides a comprehensive overview of the mechanism behind enhanced thrombogenicity accompanying COVID-19, the clinical range of NOACs, and the role of NOACs in treatment of COVID-19 based on recent investigations and clinical trials.
文献关键词：
中图分类号：
[1] 医药、卫生（R） / 内科学（R5） / 呼吸系及胸部疾病（R56） / 肺疾病（R563） / 肺炎（R563.1）
[2] 医药、卫生（R） / 药学（R9） / 药理学（R96） / 实验药理学（R965）
[3] 自动化技术、计算机技术（TP） / 计算技术、计算机技术（TP3） / 计算机的应用（TP39） / 信息处理(信息加工)（TP391）
作者姓名：
Adel Khalifa Sultan Hamad
作者机构：
Department of Electrophysiology,Mohammed bin Khalifa bin Salman Al Khalifa Cardiac Centre,Awali,Kingdom of Bahrain
文献出处：
急性病杂志（英文版）
引用格式：
[1]Adel Khalifa Sultan Hamad-.Non-vitamin K antagonist oral anticoagulants for COVID-19 thrombosis)[J].急性病杂志（英文版）,2022(06):212-221
A类：
excitement,apixaban,edoxaban,dabigatran,thrombogenicity
B类：
Non,vitamin,antagonist,oral,anticoagulants,thrombosis,Thrombotic,complications,appear,major,predictor,death,patients,multiple,studies,have,shown,that,can,help,improve,outcome,Food,Drug,Administration,acceptance,NOACs,has,sparked,much,about,their,potential,replacement,existing,target,single,clotting,often,activated,thrombin,involve,coagulation,Xa,inhibitors,including,rivaroxaban,infectious,disease,causes,events,by,inducing,inflammatory,prothrombotic,condition,This,article,provides,comprehensive,overview,mechanism,behind,enhanced,accompanying,clinical,range,role,treatment,recent,investigations,trials
AB值：
0.589049
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