Background:Beginning with the concepts of stress developed by Selye,an approach to stress and pain management,known as neuro-emotional technique(NET),has been developed.It is a treatment approach based on the principle that the stressor effects of dormant and/or current unresolved issues or trauma are what determine one's bodily responses.These responses are relatively personalized to the conditioned,experiential and emotional reality of the individual.Objective:To determine the effect of NET on patients with chronic low back pain(CLBP)over time.Design,setting,participants,and interventions:In a randomized,double-blinded,placebo-controlled study conducted in a single clinic,NET or control treatments were given twice weekly for 4 weeks in a popu-lation of 112 patients.Main outcome measures:Outcome measures,including Oswestry Disability Index,Quadruple Visual Analogue Scale,the psychoneuroimmunology markers of blood serum levels of C-reactive protein,tumour necrosis factor-α,interleukin-1(IL-1),IL-6,and IL-10,and 10 dimensions of the Short Form Health Survey scale,were assessed at baseline and at 1,3 and 6 months following the intervention period.Results:Compared to placebo,NET produced clinical and statistical significance(P＜0.001)via declines of virtually all physiological,pain and disability markers,accompanied by gains in quality-of-life indicators at 0(baseline),1,3 and 6 months.Reductions of the percentages of patients whose 5 biomarkers lay out-side the normative range were achieved at 1,3 and 6 months by NET but not control interventions.Conclusion:A randomized,controlled trial of CLBP patients indicated that 8 NET interventions,compared to placebo,produced clinically and statistically significant reductions in pain,disability and inflammatory biomarkers,and improvements in quality-of-life measures.Trial registration:The trial was registered with the Australian and New Zealand Clinical Trials Registry(No.ACTRN12608000002381).

Peter Bablis;Henry Pollard;Anthony L.Rosner

Universal Health,New South Wales 2028,Australia;School of Medical and Applied Sciences,University of Central Queensland,Brisbane,New South Wales 4000,Australia;Medical Information Services,MA 02479-4149,United States

结合医学学报（英文版）

[1]Peter Bablis;Henry Pollard;Anthony L.Rosner-.Stress reduction via neuro-emotional technique to achieve the simultaneous resolution of chronic low back pain with multiple inflammatory and biobehavioural indicators:A randomized,double-blinded,placebo-controlled trial)[J].结合医学学报（英文版）,2022(02):135-144

biobehavioural,psychoneuroimmunology,Reductions,ACTRN12608000002381

Stress,via,emotional,technique,simultaneous,resolution,chronic,back,pain,multiple,inflammatory,indicators,randomized,double,blinded,placebo,controlled,trial,Background,Beginning,concepts,developed,by,Selye,approach,management,known,NET,has,been,It,principle,that,stressor,effects,dormant,current,unresolved,issues,trauma,what,determine,bodily,responses,These,relatively,personalized,conditioned,experiential,reality,individual,Objective,To,patients,CLBP,over,Design,setting,participants,interventions,study,conducted,single,treatments,were,given,twice,weekly,weeks,popu,lation,Main,outcome,measures,Outcome,including,Oswestry,Disability,Index,Quadruple,Visual,Analogue,Scale,blood,serum,levels,reactive,protein,tumour,necrosis,interleukin,dimensions,Short,Form,Health,Survey,scale,assessed,baseline,months,following,period,Results,Compared,produced,significance,declines,virtually,physiological,disability,accompanied,gains,quality,life,percentages,whose,biomarkers,lay,side,normative,range,achieved,but,not,Conclusion,indicated,compared,clinically,statistically,significant,reductions,improvements,registration,was,registered,Australian,New,Zealand,Clinical,Trials,Registry,No

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