典型文献
Glioblastoma vaccine tumor therapy research progress
文献摘要：
Glioblastoma (GBM) is the most common primary malignancy of the central nervous system in adults. The prognosis for late-stage glioblastoma (World Health Organization grade IV astrocytic glioma) is very poor. Novel treatment options are sought after and evaluated by clinicians and researchers, and remarkable advances have been made in surgical techniques, radiotherapy, and chemotherapy. However, the treatment of glioblastoma remains extremely difficult and it can extend the lives of patients by only a few months. There has been notable progress in the field of immunotherapy, particularly with the use of tumor vaccines, for treating glioblastoma; especially peptide vaccines and cell-based vaccines such as dendritic cell vaccines and tumor cell vaccines. However, the results of the current clinical trials for vaccination are not satisfactory. This article reviews the progress in the development of vaccines for glioblastoma.
文献关键词：
Glioblastoma;Vaccine therapy;Immunotherapy;Tumor microenvironment;Review
中图分类号：
作者姓名：
Zhao Tong;Li Chunwang;Ge Hongliang;Lin Yuanxiang;Kang Dezhi
作者机构：
Department of Neurosurgery, Neurosurgery Research Institute, the First Affiliated Hospital, Fujian Medical University, Fuzhou, Fujian Province, People's Republic of China.;Fujian Key Laboratory of Precision Medicine for Cancer, the First Affiliated Hospital, Fujian Medical University, Fuzhou, Fujian Province, People's Republic of China.;Key Laboratory of Radiation Biology of Fujian higher education institutions, the First Affiliated Hospital, Fujian Medical University, Fuzhou, Fujian Province, People's Republic of China.;Clinical Research and Translation Center, the First Affiliated Hospital, Fujian Medical University, Fuzhou, Fujian Province, People's Republic of China.;Fujian Institute for brain disorders and brain science, the First Affiliated Hospital, Fujian Medical University, Fuzhou, Fujian Province, People's Republic of China.
文献出处：
引用格式：
[1]Zhao Tong;Li Chunwang;Ge Hongliang;Lin Yuanxiang;Kang Dezhi-.Glioblastoma vaccine tumor therapy research progress)[J].中华神经外科杂志（英文）,2022(02):128-132
A类：
B类：
Glioblastoma,tumor,progress,GBM,most,common,primary,malignancy,central,nervous,system,adults,prognosis,late,stage,glioblastoma,World,Health,Organization,grade,IV,astrocytic,glioma,very,poor,Novel,treatment,options,are,sought,after,evaluated,by,clinicians,researchers,remarkable,advances,have,been,made,surgical,techniques,radiotherapy,chemotherapy,However,remains,extremely,difficult,can,extend,lives,patients,only,few,months,There,has,notable,field,immunotherapy,particularly,use,vaccines,treating,especially,peptide,cell,such,dendritic,results,current,clinical,trials,vaccination,satisfactory,This,article,reviews,development,Vaccine,Immunotherapy,Tumor,microenvironment,Review
AB值：
0.651198
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