Viral infections during pregnancy are associated with adverse pregnancy outcomes, including maternal and fetal mortality, pregnancy loss, premature labor, and congenital anomalies. Mammalian gestation encounters an immunological paradox wherein the placenta balances the tolerance of an allogeneic fetus with protection against pathogens. Viruses cannot easily transmit from mother to fetus due to physical and immunological barriers at the maternal-fetal interface posing a restricted threat to the fetus and newborns. Despite this, the unknown strategies utilized by certain viruses could weaken the placental barrier to trigger severe maternal and fetal health issues especially through vertical transmission, which was not fully understood until now. In this review, we summarize diverse aspects of the major viral infections relevant to pregnancy, including the characteristics of pathogenesis, related maternal-fetal complications, and the underlying molecular and cellular mechanisms of vertical transmission. We highlight the fundamental signatures of complex placental defense mechanisms, which will prepare us to fight the next emerging and re-emerging infectious disease in the pregnancy population.

Trophoblasts;Congenital infection;Hepatitis B virus;Human immunodeficiency virus;Influenza A virus;Severe acute respiratory syndrome coronavirus 2;Zika virus

Yu Wenzhe;Hu Xiaoqian;Cao Bin

Fujian Provincial Key Laboratory of Reproductive Health Research, School of Medicine, Xiamen University, Xiamen, Fujian 361102, China;State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, Xiamen, Fujian 361102, China

母胎医学杂志（英文）

[1]Yu Wenzhe;Hu Xiaoqian;Cao Bin-.Viral Infections During Pregnancy: The Big Challenge Threatening Maternal and Fetal Health)[J].母胎医学杂志（英文）,2022(01):72-86

Trophoblasts

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