典型文献
D-tryptophan triggered epithelial-mesenchymal transition by activating TGF-β signaling pathway
文献摘要：
D-tryptophan is a special kind of nonprotein amino acid showing multiple physiological functions, but the detailed mechanisms are not fully revealed, impairing its further development and applications. This work was to investigate D-tryptophan physiological function and demonstrate the underlying mechanisms. D-tryptophan suppressed HaCaT cell proliferation but increased cell migration. Specifically, D-tryptophan decreased E-cadherin and increased Snail, Twist, and Slug expression, resulting in the development of an epithelial-mesenchymal transitions (EMT) phenomenon. Moreover, D-tryptophan promoted the expression of transforming growth factor-β (TGF-β) 1, and Smad4 knockout damages D-tryptophan's ability. These results indicated that D-tryptophan stimulated HaCaT cells to produce TGF-β1 and thus activated the TGF-β/Samd pathway, resulting in the triggering of EMT. This study revealed the molecular mechanisms of D-tryptophan activity, provided D-tryptophan as a potential approach for cancer treatment, wound healing, organ development and other relevant applications.
文献关键词：
中图分类号：
作者姓名：
Chong Wang;Fangting Wang;Yanbo Wang;Linglin Fu
作者机构：
Food Safety Key Laboratory of Zhejiang Province,School of Food Science and Biotechnology,Zhejiang Gongshang University,Hangzhou 310018,China
文献出处：
引用格式：
[1]Chong Wang;Fangting Wang;Yanbo Wang;Linglin Fu-.D-tryptophan triggered epithelial-mesenchymal transition by activating TGF-β signaling pathway)[J].食品科学与人类健康（英文）,2022(05):1215-1221
A类：
nonprotein
B类：
tryptophan,triggered,epithelial,mesenchymal,by,activating,TGF,signaling,pathway,special,kind,amino,acid,showing,multiple,physiological,functions,but,detailed,mechanisms,are,not,fully,revealed,impairing,its,further,development,applications,This,work,was,investigate,demonstrate,underlying,suppressed,HaCaT,proliferation,increased,migration,Specifically,decreased,cadherin,Snail,Twist,Slug,expression,resulting,transitions,EMT,phenomenon,Moreover,promoted,transforming,growth,Smad4,knockout,damages,ability,These,results,indicated,that,stimulated,cells,produce,thus,activated,Samd,triggering,study,molecular,activity,provided,potential,approach,cancer,treatment,wound,healing,organ,other,relevant
AB值：
0.631643
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