典型文献
Molecular mechanisms of isoflavone puerarin against cardiovascular diseases:What we know and where we go
文献摘要：
Puerarin(Pue),known as a phytoestrogen,has salient bioactivities and is promising against cardiovascu-lar diseases.This article summarizes the underlying molecular mechanisms of Pue in treating cardiovas-cular diseases,especially regulating the intracellular signal transduction,influencing ion channels,modulating the expression of microRNA,and impacting on the autophagy,which are mainly involved in the inflammatory signaling pathways,fatty acid/lipid metabolism,oxidative stress,apoptosis,and the like.The protective effect of Pue against cardiovascular diseases mainly involves attenuating the myocardial injury and decreasing the myocardial fibrosis,improving the myocardial ischemia/reperfu-sion injury,as well as inhibiting the myocardial hypertrophy and atherosclerosis.The molecular mecha-nisms of Pue's cardiovascular protective effects for the first time and comment on the state-of-the-art research methods and principles of Pue's regulation of small molecules were reviewed,so as to provide the rationale for its basic research and clinical applications.
文献关键词：
中图分类号：
作者姓名：
Weida Qin;Jianghong Guo;Wenfeng Gou;Shaohua Wu;Na Guo;Yuping Zhao;Wenbin Hou
作者机构：
Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine,Institute of Radiation Medicine,Peking Union Medical College&Chinese Academy of Medical Sciences,Tianjin 300192,China;Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China;State Key Laboratory Breeding Base of Dao-di Herbs,National Resource Center for Chinese Materia Medica,China Academy of Chinese Medical Sciences,Beijing 100700,China
文献出处：
引用格式：
[1]Weida Qin;Jianghong Guo;Wenfeng Gou;Shaohua Wu;Na Guo;Yuping Zhao;Wenbin Hou-.Molecular mechanisms of isoflavone puerarin against cardiovascular diseases:What we know and where we go)[J].中草药（英文版）,2022(02):234-243
A类：
phytoestrogen
B类：
Molecular,mechanisms,isoflavone,puerarin,against,cardiovascular,diseases,What,where,go,Puerarin,known,has,salient,bioactivities,promising,This,article,summarizes,underlying,molecular,treating,especially,regulating,intracellular,transduction,influencing,channels,modulating,expression,microRNA,impacting,autophagy,which,are,mainly,involved,inflammatory,signaling,pathways,fatty,acid,lipid,metabolism,oxidative,stress,apoptosis,like,protective,involves,attenuating,myocardial,injury,decreasing,fibrosis,improving,ischemia,reperfu,well,inhibiting,hypertrophy,atherosclerosis,effects,first,comment,state,research,methods,principles,regulation,small,molecules,were,reviewed,provide,rationale,its,basic,clinical,applications
AB值：
0.561341
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