典型文献
Successful Treatment of Severe Pityriasis Rubra Pilaris with Cyclosporine A in An Infant
文献摘要：
Introduction::Pityriasis rubra pilaris (PRP) is a rare chronic papulosquamous disease and is often difficult to treat, especially in children. Here we reported a PRP infant successfully treated by cyclosporine A.Case presentation::An 18-month-old infant with severe PRP presented with reddish follicular papules and inflammatory, infiltrated erythema over the whole body. The condition rapidly and completely responded to oral cyclosporine A. Complete clearance of the lesions was achieved within 16 weeks, and no recurrence developed during 6 months of follow-up. During both treatment and follow-up, routine blood parameters, serum creatinine, serum urea nitrogen, liver function, and blood pressure were regularly monitored once a month and remained within the reference ranges. Moreover, the child grew and developed normally and the body weight increased by 3 kg.Discussion::To date, there are not well established protocols for treatment of PRP in children. Cyclosporine A has been demonstrated to be effective treatment in psoriasis in adults and children which do not respond to some other treatments. The rapid onset of action and good efficacy of cyclosporine A were observed in our case, who achieved complete response after 16 weeks of treatment without any side effects.Conclusion::Cyclosporine A might be a safe and effective option for treating severe PRP in children.
文献关键词：
pityriasis rubra pilaris;cyclosporine A;treatment
中图分类号：
作者姓名：
Chen Ping-Jiao;Liang Jing-Yao;Li Chang-Xing;Zhang Xi-Bao
作者机构：
Department of Dermatology of Southern Hospital, Southern Medical University, Guangzhou, Guangdong 510515, China;Institute of Dermatology, Guangzhou Medical University, Guangzhou, Guangdong 510095, China;Department of Dermatology, Guangzhou Institute of Dermatology, Guangzhou, Guangdong 510095, China.
文献出处：
引用格式：
[1]Chen Ping-Jiao;Liang Jing-Yao;Li Chang-Xing;Zhang Xi-Bao-.Successful Treatment of Severe Pityriasis Rubra Pilaris with Cyclosporine A in An Infant)[J].国际皮肤性病学杂志（英文）,2022(02):110-112
A类：
Pityriasis,Rubra,Pilaris,Cyclosporine,pilaris,papulosquamous,reddish,papules,pityriasis
B类：
Successful,Treatment,Severe,An,Infant,Introduction,rubra,PRP,rare,chronic,disease,often,difficult,especially,children,Here,reported,infant,successfully,treated,by,cyclosporine,Case,presentation,old,severe,presented,follicular,inflammatory,infiltrated,erythema,whole,body,condition,rapidly,completely,responded,oral,Complete,clearance,lesions,was,achieved,within,weeks,recurrence,developed,during,months,follow,up,During,both,routine,blood,parameters,serum,creatinine,urea,nitrogen,liver,function,pressure,were,regularly,monitored,once,remained,reference,ranges,Moreover,grew,normally,weight,increased,Discussion,To,date,there,not,well,established,protocols,has,been,demonstrated,effective,psoriasis,adults,which,do,some,other,treatments,onset,action,good,efficacy,observed,our,case,response,after,without,any,side,effects,Conclusion,might,safe,option,treating
AB值：
0.547938
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