典型文献
Advanced materials for the delivery of vaccines for infectious diseases
文献摘要：
Infectious diseases are an increasing threat to global biosafety. Vaccination is the most effective and cost-efficient method for preventing and controlling infectious diseases. The development of new vaccines is inextricably linked to the advancement of materials that serve as essential components of vaccines, such as antigens, adjuvants, and their carriers. The physicochemical and biological properties of vaccines—such as the kinetics of antigen retention and presentation—are determined by the material compositions of vaccines and carriers, affecting the overall efficacy. The sustained release of antigens prolongs their retention time in germinal centers and improves humoral immune responses. Pulsatile release that imitates clinical dosing regimens can improve patient adherence to vaccination, affording increased vaccine coverage. Herein, we review progress of materials innovation on altering vaccine release kinetics, which affects the overall vaccine efficacy, safety, and compliance.
文献关键词：
Infectious disease;Vaccine;Biosafety material;Vaccine delivery;Release kinetics
中图分类号：
作者姓名：
Li Wei;Meng Junli;Ma Xinghuan;Lin Jiaqi;Lu Xueguang
作者机构：
Beijing National Laboratory for Molecular Sciences, Key Laboratory of Colloid, Interface and Chemical Thermodynamics, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China;School of Chemical Sciences, University of Chinese Academy of Sciences, Beijing 100049, China;Key State Laboratory of Fine Chemicals, School of Bioengineering, Dalian University of Technology, Dalian 116024, China
文献出处：
引用格式：
[1]Li Wei;Meng Junli;Ma Xinghuan;Lin Jiaqi;Lu Xueguang-.Advanced materials for the delivery of vaccines for infectious diseases)[J].生物安全与健康 （英文）,2022(02):95-104
A类：
Pulsatile,Biosafety
B类：
Advanced,materials,delivery,vaccines,infectious,diseases,Infectious,are,increasing,threat,global,biosafety,Vaccination,most,effective,cost,efficient,method,preventing,controlling,development,new,inextricably,linked,advancement,that,serve,essential,components,such,antigens,adjuvants,their,carriers,physicochemical,biological,properties,kinetics,retention,presentation,determined,by,compositions,affecting,overall,efficacy,sustained,release,prolongs,germinal,centers,improves,humoral,immune,responses,imitates,clinical,dosing,regimens,can,patient,adherence,vaccination,affording,increased,coverage,Herein,we,review,progress,innovation,altering,which,affects,compliance,Vaccine,Release
AB值：
0.587583
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机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
