典型文献
Efficacy of green tea extract on PC3 prostate cancer cells through upregulation of miR-195 expression and suppression of epithelial to mesenchymal transition
文献摘要：
OBJECTIVE:To evaluate anticancer efficacy of green tea extract(GTE)on PC3 prostate cancer cells.METHODS:By using quantitative real-time polymerase chain reaction(qRT-PCR)and Western blot methods,the expression of miR-195 and the epithelial to mesenchymal transition(EMT)markers such as E-cadherin and vimentin was analyzed.RESULTS:Based on the results of 2D and 3D cell culture models,the inhibition of EMT and up regulation of miR-195 expression were detected.CONCLUSIONS:Our findings will be helpful to design anti-tumor regimens with natural product original,and more studies will be required to identify the related mechanisms involving anticancer activities of green tea via miRNAs.
文献关键词：
中图分类号：
作者姓名：
Fatemeh Safari;Katayoun Dadeh Amirfard
作者机构：
Department of Biology,Faculty of Science,University of Guilan,Rasht 4193833697,Iran;Department of Microbiology,North Tehran Branch,Islamic Azad University,Tehran 1651153511,Iran
文献出处：
引用格式：
[1]Fatemeh Safari;Katayoun Dadeh Amirfard-.Efficacy of green tea extract on PC3 prostate cancer cells through upregulation of miR-195 expression and suppression of epithelial to mesenchymal transition)[J].中医杂志（英文版）,2022(05):681-686
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B类：
Efficacy,green,tea,extract,PC3,prostate,cells,through,upregulation,expression,suppression,epithelial,mesenchymal,transition,OBJECTIVE,To,evaluate,anticancer,efficacy,GTE,METHODS,By,using,quantitative,real,polymerase,chain,reaction,qRT,blot,methods,EMT,markers,such,cadherin,vimentin,was,analyzed,RESULTS,Based,results,2D,culture,models,inhibition,were,detected,CONCLUSIONS,Our,findings,will,be,helpful,design,tumor,regimens,natural,product,original,more,studies,required,identify,related,mechanisms,involving,activities,via,miRNAs
AB值：
0.641921
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