典型文献
Effectiveness and safety of red yeast rice predominated by monacolin K β-hydroxy acid form for hyperlipidemia treatment and management
文献摘要：
OBJECTIVE:To assess the lipid-lowering activity and safety of a dietary supplement containing monacolin K β-hydroxy acid form(MKA),Heye(Folium Nelumbinis),and Cangzhu(Rhizoma Atractylodis Lanceae),compared to lifestyle modifications.METHODS:Totally 117 subjects with moderate to severe dyslipidemia(according to Chinese guidelines)and low CV risk were randomly assigned into three treatment groups:lifestyle modification(LM),LM plus a low dosage of MKA,LM plus a high dosage of MKA,and treated for 60 d.The primary endpoint was the reduction of low density lipoprotein cholesterol(LDL-C)and total cholesterol(TC).Safeties along with Traditional Chinese Medicine Syndromes were assessed through the study.RESULTS:A low dosage of MKA along with lifestyle modifications caused a significant decrease in LDL-C by 15.6％on average(95％Cl,9.6％to 21％)with,a decrease in TC by 15.3％on average(95％Cl,9.26％to 21.4％),and a decrease in non-HDL-C by 35.4％(95％Cl,25.76％to 41.34％).Weak evidence of a reduction of triglycerides but an increment of HDL-C was observed in patients with severe hyperlipidemia.No severe adverse events occurred during the study.CONCLUSION:Our results confirm the LDL-C and TC lowering properties of MKA is clinically meaningful.It also produces a significant reduction of non-HDL-C,and slightly effects on TG and HDL-C as well.
文献关键词：
中图分类号：
作者姓名：
CHEN Benjian;HUANG Xiaodan;PENG Huiting;LI Yishi;CAO Yongtao;WU Huanlin;XU Danping
作者机构：
Department of Medical,Guangdong Provincial Hospital of Chinese Medicine,The Second Affiliated Hospital of Guangzhou University of Chinese Medicine,Guangzhou 510120,China;the Second Clinical College,Guangzhou University of Chinese Medicine,Guangzhou 510405,China;the First Clinical College,Guangzhou University of Chinese Medicine,Guangzhou 510405,China;Department of Mathematical&Computer Sciences,Indiana University of Pennsylvania,Indiana 15705,PA,USA;Department of Cardiology,Dongzhimen Hospital,Beijing University of Chinese Medicine,Beijing 350122,China;Department of Traditional Chinese Medicine,the Eighth Affiliated Hospital,SunYat-Sen University,Shenzhen 518033,China
文献出处：
引用格式：
[1]CHEN Benjian;HUANG Xiaodan;PENG Huiting;LI Yishi;CAO Yongtao;WU Huanlin;XU Danping-.Effectiveness and safety of red yeast rice predominated by monacolin K β-hydroxy acid form for hyperlipidemia treatment and management)[J].中医杂志（英文版）,2022(02):264-271
A类：
monacolin,MKA,Heye,Nelumbinis,Cangzhu,Lanceae,Safeties,Syndromes
B类：
Effectiveness,safety,yeast,rice,predominated,by,hydroxy,acid,form,hyperlipidemia,treatment,management,OBJECTIVE,lowering,activity,dietary,supplement,containing,Folium,Rhizoma,Atractylodis,compared,lifestyle,modifications,METHODS,Totally,subjects,moderate,severe,dyslipidemia,according,Chinese,guidelines,CV,risk,were,randomly,assigned,into,three,groups,LM,plus,dosage,high,treated,primary,endpoint,was,reduction,density,lipoprotein,cholesterol,LDL,total,along,Traditional,Medicine,assessed,through,study,RESULTS,caused,significant,decrease,average,Cl,HDL,Weak,evidence,triglycerides,but,increment,observed,patients,No,adverse,events,occurred,during,CONCLUSION,Our,results,confirm,properties,clinically,meaningful,It,also,produces,slightly,effects,well
AB值：
0.503853
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