典型文献
Acetylsalicylic acid for metal stent in malignant distal common bile duct obstruction:A randomized controlled trial
文献摘要：
Background:Endoscopic biliary drainage is the treatment of choice for patients with malignant distal common bile duct obstruction.Self-expandable metal stents have clinical advantages including an in-creased duration of patency that may be prolonged by acetylsalicylic acid(ASA)use.The aim of this study was to investigate whether ASA had a positive effect on the patency of self-expandable metal stents compared with placebo.Methods:This prospective,multicenter,double-blinded,and randomized placebo-controlled trial was conducted from October 2017 to May 2020 in Korea.Patients who underwent palliative endoscopic bil-iary drainage with self-expandable metal stents for malignant distal bile duct obstruction were enrolled,and allocated to ASA treatment or placebo.The study outcomes were the rate of stent dysfunction at 6 months,duration of stent patency,risk factors for stent dysfunction,and any adverse events.Results:Interim analysis included 24 and 28 patients in the ASA and placebo groups,respectively.There was no significant difference between the ASA and placebo groups in stent dysfunction(25.0％vs.20.7％,P=0.761)or the duration of stent patency(150.97±10.55 vs.158.07±8.70 days,P=0.497).Six patients experienced suspected ASA-related adverse events,and there was one lethal case.Conclusions:ASA did not prolong stent patency.This study was terminated early because of the possibil-ity of serious adverse events related to ASA treatment of these patients receiving palliative care.
文献关键词：
中图分类号：
作者姓名：
Jin Ho Choi;Kyong Joo Lee;Woo Hyun Paik;Namyoung Parka;Jung Won Chun;Sang Hyub Lee;Ji Kon Ryu;Yong-Tae Kim
作者机构：
Department of Internal Medicine,Liver Research Institute,Seoul National University College of Medicine,Seoul,Korea;Department of Internal Medicine,Yonsei University Wonju College of Medicine,Wonju,Korea
文献出处：
引用格式：
[1]Jin Ho Choi;Kyong Joo Lee;Woo Hyun Paik;Namyoung Parka;Jung Won Chun;Sang Hyub Lee;Ji Kon Ryu;Yong-Tae Kim-.Acetylsalicylic acid for metal stent in malignant distal common bile duct obstruction:A randomized controlled trial)[J].国际肝胆胰疾病杂志(英文版),2022(05):493-499
A类：
Acetylsalicylic,patency,iary
B类：
acid,metal,malignant,distal,common,bile,obstruction,randomized,controlled,trial,Background,Endoscopic,biliary,drainage,treatment,choice,patients,Self,expandable,stents,have,clinical,advantages,including,creased,duration,that,may,prolonged,by,acetylsalicylic,ASA,aim,this,study,was,investigate,whether,had,positive,effect,self,compared,placebo,Methods,This,prospective,multicenter,double,blinded,conducted,from,October,May,Korea,Patients,who,underwent,palliative,endoscopic,were,enrolled,allocated,outcomes,rate,dysfunction,months,risk,factors,any,adverse,events,Results,Interim,analysis,included,groups,respectively,There,significant,difference,between,days,Six,experienced,suspected,related,there,one,lethal,case,Conclusions,did,not,terminated,early,because,possibil,ity,serious,these,receiving,care
AB值：
0.477708
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