Background:Patients commonly develop postoperative pain after total knee arthroplasty(TKA).Acupuncture-related techniques and low-level laser therapy could be beneficial for pain management for older individuals.Objective:To examine the effect of low-level laser acupuncture(LA)in reducing postoperative pain,pain-related interference in daily life,morphine consumption,and morphine-related side effects in older patients with knee osteoarthritis who underwent TKA.Design,setting,participants and intervention:A single-blind randomized placebo-controlled trial was con-ducted.Patients(N=82)were recruited and randomly assigned via a computer-generated list to the LA group or a placebo group.The LA group received low-level laser therapy at Sanyinjiao(SP6),Taixi(K13),Kunlun(BL60),Fengshi(GB31),Futu(ST32)and Neiguan(PC6)after TKA,while the placebo acupuncture group received the same treatment procedure without laser energy output.Main outcome measures:The primary outcome was postoperative pain intensity,and it was measured at baseline and hours 2,6,10,24,48 and 72 after TKA.The secondary outcomes,including relative pain,postoperative pain-related interference in daily life and morphine consumption,were measured at hours 24,48 and 72 after TKA Results:Generalized estimating equations revealed significant between-group differences in pain inten-sity(P=0.01),and trend differences in pain intensity for the LA group starting at hours 10 to 72(P＜0.05)and morphine consumption at hours 48 and 72(P＜0.05).The changes in pain-related interference in daily life were significant(P＜0.05)at 72 h,with the exception of the parameters for worst pain,mood,and sleep.Nausea and vomiting side effects from morphine had significant between-group differences at hours 10 and 24(P＜0.05).Conclusion:Low-level LA gradually reduced older patients'postoperative pain intensity and morphine consumption within the first 72 h after their TKA for osteoarthritis.Low-level LA may have benefits as an adjuvant pain management technique for clinical care.Trial registration:ClinicalTrials.gov registration number NCT03995446.

Chiung-Hui Huang;Mei-Ling Yeh;Fang-Pey Chen;Daphne Wu

Department of Nursing,Taipei Veterans General Hospital,Taipei City 11217,Taiwan,China;School of Nursing National Taipei University of Nursing and Health Sciences,Taipei City 11219,Taiwan,China;Center for Traditional Medicine,Taipei Veterans General Hospital,Taipei City 11217,Taiwan,China;Scool of Nursing,National Taipei University of Nursing and Health Sciences and School of Medicine,Taipei City 11217,Taiwan,China

结合医学学报（英文版）

[1]Chiung-Hui Huang;Mei-Ling Yeh;Fang-Pey Chen;Daphne Wu-.Low-level laser acupuncture reduces postoperative pain and morphine consumption in older patients with total knee arthroplasty:A randomized placebo-controlled trial)[J].结合医学学报（英文版）,2022(04):321-328

BL60,Fengshi,GB31,Futu,ST32,Neiguan,Nausea,NCT03995446

Low,level,laser,acupuncture,reduces,postoperative,pain,morphine,consumption,older,patients,total,knee,arthroplasty,randomized,placebo,controlled,trial,Background,Patients,commonly,develop,after,TKA,Acupuncture,related,techniques,low,therapy,could,beneficial,management,individuals,Objective,To,examine,LA,reducing,interference,daily,life,side,effects,osteoarthritis,who,underwent,Design,setting,participants,intervention,single,blind,was,ducted,were,recruited,randomly,assigned,via,computer,generated,list,group,received,Sanyinjiao,SP6,Taixi,K13,Kunlun,PC6,while,same,treatment,procedure,without,energy,output,Main,measures,primary,intensity,measured,baseline,hours,secondary,outcomes,including,relative,Results,Generalized,estimating,equations,revealed,significant,between,differences,trend,starting,changes,exception,parameters,worst,mood,sleep,vomiting,from,had,Conclusion,gradually,reduced,within,first,their,may,have,benefits,adjuvant,clinical,care,registration,ClinicalTrials,gov,number

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