典型文献
Tc17 cells in autoimmune diseases
文献摘要：
Multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE), a pathologically similar disease used to model MS in rodents, are typical CD4
+ T cell-dominated autoimmune diseases. CD4
+ interleukin (IL)17
+ T cells (Th17 cells) have been well studied and have shown that they play a critical role in the pathogenesis of MS/EAE. However, studies have suggested that CD8
+IL17
+ T cells (Tc17 cells) have a similar phenotype and cytokine and transcription factor profiles to those of Th17 cells and have been found to be crucial in the pathogenesis of autoimmune diseases, including MS/EAE, psoriasis, type I diabetes, rheumatoid arthritis, and systemic lupus erythematosus. However, the evidence for this is indirect and insufficient. Therefore, we searched for related publications and attempted to summarize the current knowledge on the role of Tc17 cells in the pathogenesis of MS/EAE, as well as in the pathogenesis of other autoimmune diseases, and to find out whether Tc17 cells or Th17 cells play a more critical role in autoimmune disease, especially in MS and EAE pathogenesis, or whether the interaction between these two cell types plays a critical role in the development of the disease.
文献关键词：
Tc17;Autoimmune diseases;Multiple sclerosis;Experimental autoimmune encephalomyelitis;Retinoic acid receptor-related orphan receptor gamma;Th17
中图分类号：
作者姓名：
Peng Yong;Deng Xiang;Zeng Qiuming;Tang Yandan
作者机构：
Department of Neurology, Affiliated First Hospital of Hunan Traditional Chinese Medical College, Zhuzhou, Hunan 412000, China;Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China
文献出处：
引用格式：
[1]Peng Yong;Deng Xiang;Zeng Qiuming;Tang Yandan-.Tc17 cells in autoimmune diseases)[J].中华医学杂志（英文版）,2022(18):2167-2177
A类：
+IL17
B类：
Tc17,cells,autoimmune,diseases,Multiple,sclerosis,experimental,encephalomyelitis,EAE,pathologically,similar,used,model,rodents,are,typical,CD4
,dominated,interleukin,Th17,have,been,well,studied,shown,that,they,critical,role,pathogenesis,However,studies,suggested,CD8
,phenotype,cytokine,transcription,profiles,those,found,crucial,including,psoriasis,diabetes,rheumatoid,arthritis,systemic,lupus,erythematosus,evidence,this,indirect,insufficient,Therefore,searched,related,publications,attempted,summarize,current,knowledge,other,find,out,whether,more,especially,interaction,between,these,two,types,plays,development,Autoimmune,Experimental,Retinoic,acid,receptor,orphan,gamma
AB值：
0.468767
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机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
