典型文献
Protein kinases in cardiovascular diseases
文献摘要：
Cardiovascular disease (CVD) remains the leading cause of death worldwide. Therefore, exploring the mechanism of CVDs and critical regulatory factors is of great significance for promoting heart repair, reversing cardiac remodeling, and reducing adverse cardiovascular events. Recently, significant progress has been made in understanding the function of protein kinases and their interactions with other regulatory proteins in myocardial biology. Protein kinases are positioned as critical regulators at the intersection of multiple signals and coordinate nearly every aspect of myocardial responses, regulating contractility, metabolism, transcription, and cellular death. Equally, reconstructing the disrupted protein kinases regulatory network will help reverse pathological progress and stimulate cardiac repair. This review summarizes recent researches concerning the function of protein kinases in CVDs, discusses their promising clinical applications, and explores potential targets for future treatments.
文献关键词：
Protein kinases;Signal transduction;Cardiovascular diseases;Phosphorylation
中图分类号：
作者姓名：
Chen Jiawen;Li Yafei;Du Chong;Wei Tianwen;Shan Tiankai;Wang Liansheng
作者机构：
Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing Medical University, Nanjing, Jiangsu 210029, China
文献出处：
引用格式：
[1]Chen Jiawen;Li Yafei;Du Chong;Wei Tianwen;Shan Tiankai;Wang Liansheng-.Protein kinases in cardiovascular diseases)[J].中华医学杂志（英文版）,2022(05):557-570
A类：
Equally
B类：
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AB值：
0.676188
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