典型文献
Genetics of anorexia nervosa:An overview of genome-wide association studies and emerging biological links
文献摘要：
Anorexia nervosa(AN)is a complex disorder with a strong genetic component.Comorbidities are frequent and there is substantial overlap with other disorders.The lack of understanding of the molecular and neuroanatomical causes has made it difficult to develop effective treatments and it is often difficult to treat in clinical practice.Recent advances in genetics have changed our understanding of polygenic diseases,increasing the possibility of understanding better how molecular pathways are intertwined.This review synthetizes the current state of genetic research providing an overview of genome-wide association studies(GWAS)findings in AN as well as overlap with other disorders,traits,pathways,and imaging results.This paper also discusses the different putative global pathways that are contributing to the disease including the evidence for metabolic and psychiatric origin of the disease.
文献关键词：
中图分类号：
作者姓名：
Clara de Jorge Martínez;Gull Rukh;Michael J.Williams;Santino Gaudio;Samantha Brooks;Helgi B.Schi?th
作者机构：
Department of Neuroscience,Functional Pharmacology,Uppsala University,Uppsala,Sweden;Department of Biomedicine and Prevention,University of Rome Tor Vergata,Rome,Italy;School of Psychology,Faculty of Health,Liverpool John Moores University,UK;Department of Psychology,School of Human and Community Development,University of the Witwatersrand,Johannesburg,South Africa;Institute for Translational Medicine and Biotechnology,Sechenov First Moscow State Medical University,Moscow,Russia
文献出处：
引用格式：
[1]Clara de Jorge Martínez;Gull Rukh;Michael J.Williams;Santino Gaudio;Samantha Brooks;Helgi B.Schi?th-.Genetics of anorexia nervosa:An overview of genome-wide association studies and emerging biological links)[J].遗传学报,2022(01):1-12
A类：
Anorexia,synthetizes
B类：
Genetics,anorexia,nervosa,overview,genome,wide,association,studies,emerging,biological,links,AN,complex,strong,component,Comorbidities,are,frequent,there,substantial,overlap,other,disorders,lack,understanding,molecular,neuroanatomical,causes,has,made,difficult,develop,effective,treatments,often,clinical,practice,Recent,advances,genetics,have,changed,our,polygenic,diseases,increasing,possibility,better,how,pathways,intertwined,This,review,current,state,research,providing,GWAS,findings,well,traits,imaging,results,paper,also,discusses,different,putative,global,that,contributing,including,evidence,metabolic,psychiatric,origin
AB值：
0.614907
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