典型文献
Targeting PI3K/AKT signaling for treatment of idiopathic pulmonary fibrosis
文献摘要：
Idiopathic pulmonary fibrosis(IPF)is a chronic progressive fibrotic interstitial pneumonia with unknown causes.The incidence rate increases year by year and the prognosis is poor without cure.Recently,phosphatidylinositol 3-kinase(PI3K)/protein kinase B(PKB/AKT)signaling pathway can be considered as a master regulator for IPF.The contribution of the PI3K/AKT in fibrotic processes is increasingly prominent,with PI3K/AKT inhibitors currently under clinical evaluation in IPF.Therefore,PI3K/AKT represents a critical signaling node during fibrogenesis with potential implications for the development of novel anti-fibrotic strategies.This review epitomizes the progress that is being made in understanding the complex interpretation of the cause of IPF,and demonstrates that PI3K/AKT can directly participate to the greatest extent in the formation of IPF or cooperate with other pathways to pro-mote the development of fibrosis.We further summarize promising PI3K/AKT inhibitors with IPF treat-ment benefits,including inhibitors in clinical trials and pre-clinical studies and natural products,and discuss how these inhibitors mitigate fibrotic progression to explore possible potential agents,which will help to develop effective treatment strategies for IPF in the near future.
文献关键词：
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作者姓名：
Jincheng Wang;Kaili Hu;Xuanyan Cai;Bo Yang;Qiaojun He;Jiajia Wang;Qinjie Weng
作者机构：
Center for Drug Safety Evaluation and Research,College of Pharmaceutical Sciences,Zhejiang University,Hangzhou 310058,China;Hangzhou Institute of Innovative Medicine,College of Pharmaceutical Sciences,Zhejiang University,Hangzhou 310058,China
文献出处：
引用格式：
[1]Jincheng Wang;Kaili Hu;Xuanyan Cai;Bo Yang;Qiaojun He;Jiajia Wang;Qinjie Weng-.Targeting PI3K/AKT signaling for treatment of idiopathic pulmonary fibrosis)[J].药学学报（英文版）,2022(01):18-32
A类：
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B类：
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AB值：
0.564349
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