典型文献
Targeting papain-like protease for broad-spectrum coronavirus inhibition
文献摘要：
The emergence of SARS-CoV-2 variants of concern and repeated outbreaks of coronavirus epidemics in the past two decades emphasize the need for next-generation pan-coronaviral therapeutics.Drugging the multi-func-tional papain-like protease(PLpro)domain of the viral nsp3 holds promise.However,none of the known coronavirus PLpro inhibitors has been shown to be in vivo active.Herein,we screened a structurally diverse library of 50,080 compounds for potential coronavirus PLpro inhibitors and identified a noncovalent lead
文献关键词：
中图分类号：
作者姓名：
Shuofeng Yuan;Xiaopan Gao;Kaiming Tang;Jian-Piao Cai;Menglong Hu;Peng Luo;Lei Wen;Zi-Wei Ye;Cuiting Luo;Jessica Oi-Ling Tsang;Chris Chun-Yiu Chan;Yaoqiang Huang;Jianli Cao;Ronghui Liang;Zhenzhi Qin;Bo Qin;Feifei Yin;Hin Chu;Dong-Yan Jin;Ren Sun;Jasper Fuk-Woo Chan;Sheng Cui;Kwok-Yung Yuen
作者机构：
State Key Laboratory of Emerging Infectious Diseases, Li Ka Shing Faculty of Medicine, The University of Hong Kong,
Pokfulam, Hong Kong SAR,China;NHC Key Laboratory of Systems Biology of Pathogens,Institute of Pathogen Biology,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100730,China;Department of Microbiology,Li Ka Shing,Faculty of Medicine,The University of Hong Kong,Pokfulam,Hong Kong SAR,China;School of Biomedical Sciences,Li Ka Shing Faculty of Medicine,The University of Hong Kong,Pokfulam,Hong Kong SAR,China;Key Laboratory of Tropical Translational Medicine of Ministry of Education,Hainan Medical University,Haikou 571199,China;Academician Workstation of Hainan Province,Hainan Medical University,Haikou 571199,China;Hainan Medical University-The University of Hong Kong Joint Laboratory of Tropical Infectious Diseases,The University of Hong Kong,Pokfulam,Hong Kong Special Administrative Region,China;State Key Laboratory of Emerging Infectious Diseases,Li Ka Shing Faculty of Medicine,The University of Hong Kong,Pokfulam,Hong Kong SAR,China;Guangzhou Laboratory,Guangzhou 510320,China;Department of Molecular and Medical Pharmacology,David Geffen School of Medicine,University of California Los Angeles,Los Angeles,CA,USA;Department of Clinical Microbiology and Infection Control,The University of Hong Kong-Shenzhen Hospital,Shenzhen 518053,China
文献出处：
引用格式：
[1]Shuofeng Yuan;Xiaopan Gao;Kaiming Tang;Jian-Piao Cai;Menglong Hu;Peng Luo;Lei Wen;Zi-Wei Ye;Cuiting Luo;Jessica Oi-Ling Tsang;Chris Chun-Yiu Chan;Yaoqiang Huang;Jianli Cao;Ronghui Liang;Zhenzhi Qin;Bo Qin;Feifei Yin;Hin Chu;Dong-Yan Jin;Ren Sun;Jasper Fuk-Woo Chan;Sheng Cui;Kwok-Yung Yuen-.Targeting papain-like protease for broad-spectrum coronavirus inhibition)[J].蛋白质与细胞,2022(12):940-953
A类：
coronaviral,Drugging,nsp3
B类：
Targeting,papain,like,protease,broad,spectrum,coronavirus,inhibition,emergence,SARS,CoV,variants,concern,repeated,outbreaks,epidemics,past,two,decades,emphasize,need,next,generation,pan,therapeutics,multi,func,tional,PLpro,domain,holds,promise,However,none,known,inhibitors,been,shown,vivo,active,Herein,screened,structurally,diverse,library,compounds,potential,identified,noncovalent,lead
AB值：
0.645574
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机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
