典型文献
New pathogenic insights from large animal models of neurodegenerative diseases
文献摘要：
Animal models are essential for investigating the pathogenesis and developing the treatment of human diseases.Identification of genetic mutations responsi-ble for neurodegenerative diseases has enabled the creation of a large number of small animal models that mimic genetic defects found in the affected individuals.Of the current animal models,rodents with genetic modifications are the most commonly used animal models and provided important insights into pathogen-esis.However,most of genetically modified rodent models lack overt neurodegeneration,imposing chal-lenges and obstacles in utilizing them to rigorously test the therapeutic effects on neurodegeneration.Recent studies that used CRISPR/Cas9-targeted large animal(pigs and monkeys)have uncovered important patho-logical events that resemble neurodegeneration in the patient's brain but could not be produced in small animal models.Here we highlight the unique nature of large animals to model neurodegenerative diseases as well as the limitations and challenges in establishing large ani-mal models of neurodegenerative diseases,with focus on Huntington disease,Amyotrophic lateral sclerosis,and Parkinson diseases.We also discuss how to use the important pathogenic insights from large animal models to make rodent models more capable of recapitulating important pathological features of neurodegenerative diseases.
文献关键词：
中图分类号：
作者姓名：
Peng Yin;Shihua Li;Xiao-Jiang Li;Weili Yang
作者机构：
Guangdong Key Laboratory of Non-human Primate Research,Guangdong-Hongkong-Macau Institute of CNS Regeneration,Jinan University,Guangzhou 510632,China
文献出处：
引用格式：
[1]Peng Yin;Shihua Li;Xiao-Jiang Li;Weili Yang-.New pathogenic insights from large animal models of neurodegenerative diseases)[J].蛋白质与细胞,2022(10):707-720
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