典型文献
Therapeutic cell engineering:designing programmable synthetic genetic circuits in mammalian cells
文献摘要：
Cell therapy approaches that employ engineered mam-malian cells for on-demand production of therapeutic agents in the patient's body are moving beyond proof-of-concept in translational medicine.The therapeutic cells can be customized to sense user-defined signals,pro-cess them,and respond in a programmable and pre-dictable way.In this paper,we introduce the available tools and strategies employed to design therapeutic cells.Then,various approaches to control cell behav-iors,including open-loop and closed-loop systems,are discussed.We also highlight therapeutic applications of engineered cells for early diagnosis and treatment of various diseases in the clinic and in experimental dis-ease models.Finally,we consider emerging technolo-gies such as digital devices and their potential for incorporation into future cell-based therapies.
文献关键词：
中图分类号：
作者姓名：
Maysam Mansouri;Martin Fussenegger
作者机构：
Department of Biosystems Science and Engineering,ETH Zurich,Mattenstrasse 26,4058 Basel,Switzerland;Faculty of Science,University of Basel,Mattenstrasse 26,4058 Basel,Switzerland
文献出处：
引用格式：
[1]Maysam Mansouri;Martin Fussenegger-.Therapeutic cell engineering:designing programmable synthetic genetic circuits in mammalian cells)[J].蛋白质与细胞,2022(07):476-489
A类：
dictable
B类：
Therapeutic,engineering,designing,programmable,synthetic,genetic,circuits,mammalian,cells,Cell,therapy,approaches,that,engineered,demand,production,therapeutic,agents,patient,body,are,moving,beyond,proof,concept,translational,medicine,can,customized,sense,user,defined,signals,cess,them,respond,pre,way,In,this,paper,we,introduce,available,tools,strategies,employed,Then,various,control,behav,iors,including,open,loop,closed,systems,discussed,We,also,highlight,applications,early,diagnosis,treatment,diseases,clinic,experimental,models,Finally,consider,emerging,technolo,such,digital,devices,their,potential,incorporation,into,future,therapies
AB值：
0.661439
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