典型文献
DNA damage repair promotion in colonic epithelial cells by andrographolide downregulated cGAS-STING pathway activation and contributed to the relief of CPT-11-induced intestinal mucositis
文献摘要：
Gastrointestinal mucositis is one of the most debilitating side effects of the chemotherapeutic agent irinotecan(CPT-11).Andrographolide,a natural bicyclic diterpenoid lactone,has been reported to possess anti-colitis activity.In this study,andrographolide treatment was found to significantly relieve CPT-11-induced colitis in tumor-bearing mice without decreasing the tumor suppression effect of CPT-11.CPT-11 causes DNA damage and the release of double-stranded DNA(dsDNA)from the intes-tine,leading to cyclic-GMP-AMP synthase(cGAS)-stimulator of interferon genes(STING)-mediated colitis,which was significantly decreased by andrographolide both in vivo and in vitro.Mechanistic studies revealed that andrographolide could promote homologous recombination(HR)repair and down-regulate dsDNA-cGAS-STING signaling and contribute to the improvement of CPT-11-induced gastro-intestinal mucositis.These results suggest that andrographolide may be a novel agent to relieve gastrointestinal mucositis caused by CPT-11.
文献关键词：
中图分类号：
作者姓名：
Yuanyuan Wang;Bin Wei;Danping Wang;Jingjing Wu;Jianhua Gao;Haiqing Zhong;Yang Sun;Qiang Xu;Wen Liu;Yanhong Gu;Wenjie Guo
作者机构：
Department of Oncology,the First Affiliated Hospital of Nanjing Medical University,Nanjing 210029,China;Cancer Rehabilitation Center,Jiangsu Province Hospital,Nanjing 210029,China;Department of Oncology,the Affiliated Huai'an No.l People's Hospital of Nanjing Medical University,Huai'an 223300,China;State Key Laboratory of Pharmaceutical Biotechnology,School of Life Sciences,Nanjing University,Nanjing 210023,China
文献出处：
引用格式：
[1]Yuanyuan Wang;Bin Wei;Danping Wang;Jingjing Wu;Jianhua Gao;Haiqing Zhong;Yang Sun;Qiang Xu;Wen Liu;Yanhong Gu;Wenjie Guo-.DNA damage repair promotion in colonic epithelial cells by andrographolide downregulated cGAS-STING pathway activation and contributed to the relief of CPT-11-induced intestinal mucositis)[J].药学学报（英文版）,2022(01):262-273
A类：
B类：
damage,repair,promotion,colonic,epithelial,cells,by,andrographolide,downregulated,cGAS,STING,pathway,activation,contributed,relief,CPT,induced,mucositis,Gastrointestinal,most,debilitating,side,effects,chemotherapeutic,agent,irinotecan,Andrographolide,natural,bicyclic,diterpenoid,lactone,been,reported,possess,anti,colitis,activity,In,this,study,treatment,was,found,significantly,relieve,tumor,bearing,mice,without,decreasing,suppression,causes,release,double,stranded,dsDNA,from,tine,leading,GMP,AMP,synthase,stimulator,interferon,genes,mediated,which,decreased,both,vivo,vitro,Mechanistic,studies,revealed,that,could,promote,homologous,recombination,signaling,improvement,These,results,suggest,may,novel,gastrointestinal,caused
AB值：
0.588416
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