典型文献
A Novel Vascular Disrupting Agents Noncovalent Polymeric Nanomedicine:Significantly Increased Antitumor Therapeutic Efficiency
文献摘要：
Plinabulin,a potential vascular disrupting agent(VDA),has entered the phase Ⅲ clinical trial.However,the antitumor efficacy of Plinabulin is only moderate,which is probably because of the short action time of acting on tubulin.To maintain a constant VDAs concentration around the tumor vascular endothelial cells,in this study,we developed a novel Plinabulin derivate named HBP and further prepared noncovalent HBP nanoparticles(HBP NPs).We examined and compared the antitumor efficiency of HBP and HBP NPs in 4T1 tumor-bearing mice.HBP NPs significantly increased therapeutic efficiency than HBP,even with a quarter dose.These findings exhibited in this paper further confirmed the opinion that VDAs nanomedicine could markedly enhance tumor therapeutic effect more than small molecular VDAs.
文献关键词：
中图分类号：
作者姓名：
Jianlin Lv;Yajun Xu;Yue Huang;Haiyang Yu;Zhaohui Tang
作者机构：
Key Laboratory of Polymer Ecomaterials,Changchun Institute of Applied Chemistry,Chinese Academy of Sciences,Changchun,Jilin 130022,China;School of Applied Chemistry and Engineering,University of Science and Technology of China,Hefei,Anhui 230026,China;Jilin Biomedical Polymers Engineering Laboratory,5625 Renmin Street,Changchun,Jilin 130022,China
文献出处：
引用格式：
[1]Jianlin Lv;Yajun Xu;Yue Huang;Haiyang Yu;Zhaohui Tang-.A Novel Vascular Disrupting Agents Noncovalent Polymeric Nanomedicine:Significantly Increased Antitumor Therapeutic Efficiency)[J].中国化学（英文版）,2022(12):1447-1456
A类：
Noncovalent,Plinabulin,VDAs,derivate
B类：
Novel,Vascular,Disrupting,Agents,Polymeric,Nanomedicine,Significantly,Increased,Antitumor,Therapeutic,Efficiency,potential,vascular,disrupting,agent,entered,phase,clinical,trial,However,antitumor,efficacy,only,moderate,which,probably,because,short,action,acting,tubulin,To,maintain,constant,concentration,around,endothelial,cells,this,study,developed,novel,named,HBP,further,prepared,noncovalent,nanoparticles,NPs,We,examined,compared,efficiency,4T1,bearing,mice,significantly,increased,therapeutic,than,even,quarter,dose,These,findings,exhibited,paper,confirmed,opinion,that,nanomedicine,could,markedly,enhance,effect,more,small,molecular
AB值：
0.629347
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