典型文献
Microfluidic production of liposomes through liquid-liquid phase separation in ternary droplets
文献摘要：
Liposomes,the self-assembled phospholipid vesicles,have been extensively used in various fields such as artificial cells,drug delivery systems,biosensors and cosmetics.However,current microfluidic routes to lipo-somes mostly rely on water-in-oil-in-water double emul-sion droplets as templates,and require complex fabrication of microfluidic devices,and tedious manipulation of multiphase fluids.Here we present a simple microfluidic approach to preparing monodisperse liposomes from oil-in-water droplets.For demonstration,we used butyl acetate-water-ethanol ternary mixtures as inner phase and an aqueous solution of surfactants as outer phase to make oil-in-water droplets,which can evolve into water-in-oil-in-water double emulsion droplets by liquid-liquid phase separation of ternary mixtures.Subsequently,the resultant water-in-oil-in-water droplets underwent a dewetting transition to form separated monodisperse liposomes and residual oil droplets,with the assistance of surfactants.The method is simple,does not require complex microfluidic devices and tedious manipulation,and provides a new platform for controllable preparation of liposomes.
文献关键词：
中图分类号：
作者姓名：
Xu-Chun Song;Zi-Han Zhou;Ya-Lan Yu;Nan-Nan Deng
作者机构：
College of Chemistry and Chemical Engineering,Southwest Petroleum University,Chengdu 610500,China;School of Chemistry and Chemical Engineering,Shanghai Jiao Tong University,Shanghai 200240,China
文献出处：
引用格式：
[1]Xu-Chun Song;Zi-Han Zhou;Ya-Lan Yu;Nan-Nan Deng-.Microfluidic production of liposomes through liquid-liquid phase separation in ternary droplets)[J].化学科学与工程前沿,2022(06):1017-1022
A类：
emul
B类：
Microfluidic,production,liposomes,through,liquid,separation,ternary,droplets,Liposomes,self,assembled,phospholipid,vesicles,have,been,extensively,used,various,fields,such,artificial,cells,drug,delivery,systems,biosensors,cosmetics,However,current,microfluidic,routes,mostly,rely,water,oil,double,templates,require,complex,fabrication,devices,tedious,manipulation,multiphase,fluids,Here,present,simple,approach,preparing,monodisperse,from,For,demonstration,butyl,acetate,ethanol,mixtures,inner,aqueous,solution,surfactants,outer,make,which,can,evolve,into,emulsion,by,Subsequently,resultant,underwent,dewetting,transition,separated,residual,assistance,method,does,not,provides,new,platform,controllable,preparation
AB值：
0.542058
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