典型文献
Urinary concentrations of phenols,oxidative stress biomarkers and thyroid cancer:Exploring associations and mediation effects
文献摘要：
Phenols have been shown to influence the cellular proliferation and function of thyroid in experimental models.However,few human studies have investigated the association be-tween phenol exposure and thyroid cancer,and the underlying mechanisms are also poorly understood.We conducted a case-control study by age-and sex-matching 143 thyroid can-cer and 224 controls to investigate the associations between phenol exposures and the risk of thyroid cancer,and further to explore the mediating role of oxidative stress.We found that elevated urinary triclosan(TCS),bisphenol A(BPA)and bisphenol S(BPS)levels were asso-ciated with increased risk of thyroid cancer(all P for trends＜0.05),and the adjusted odds ratios(ORs)comparing the extreme exposure groups were 3.52(95％confidence interval(CI):2.08,5.95),2.06(95％CI:1.06,3.97)and 7.15(95％CI:3.12,16.40),respectively.Positive asso-ciations were also observed between urinary TCS,BPA and BPS and three oxidative stress biomarkers measured by 8-hydroxy-2'-deoxyguanosine(8-OHdG),8-iso-prostaglandin F2α(8-isoPGF2α)and 4-hydroxy-2-nonenal-mercapturic acid(HNE-MA),as well as between uri-nary 8-isoPGF2α and HNE-MA and the risk of thyroid cancer.Mediation analysis showed that urinary 8-isoPGF2α mediated 28.95％,47.06％and 31.08％of the associations between TCS,BPA and BPS exposures and the risk of thyroid cancer,respectively(all P＜0.05).Our results suggest that exposure to TCS,BPA and BPS may be associated with increased risk of thyroid cancer and lipid peroxidation may be an intermediate mechanism.Further studies are warranted to confirm the findings.
文献关键词：
中图分类号：
作者姓名：
Pan-Pan Chen;Pan Yang;Chong Liu;Yan-Ling Deng;Qiong Luo;Yu Miao;Min Zhang;Fei-Peng Cui;Jia-Yue Zeng;Tian Shi;Ting-Ting Lu;Da Chen;Long-Qiang Wang;Chun-Ping Liu;Ming Jiang;Qiang Zeng
作者机构：
Department of Occupational and Environmental Health,School of Public Health,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China;Key Laboratory of Environment and Health,Ministry of Education&Ministry of Environmental Protection,and State Key Laboratory of Environmental Health(incubating),School of Public Health,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China;Department of Public Health and Preventive Medicine,School of Medicine,Jinan University,Guangzhou 510632,China;School of Environment,Guangdong Key Laboratory of Environmental Pollution and Health,Jinan University,Guangzhou 510632,China;Department of Thyroid and Breast Surgery,the Central Hospital of Wuhan,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022,China;Department of Thyroid and Breast Surgery,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430014,China
文献出处：
引用格式：
[1]Pan-Pan Chen;Pan Yang;Chong Liu;Yan-Ling Deng;Qiong Luo;Yu Miao;Min Zhang;Fei-Peng Cui;Jia-Yue Zeng;Tian Shi;Ting-Ting Lu;Da Chen;Long-Qiang Wang;Chun-Ping Liu;Ming Jiang;Qiang Zeng-.Urinary concentrations of phenols,oxidative stress biomarkers and thyroid cancer:Exploring associations and mediation effects)[J].环境科学学报（英文版）,2022(10):30-40
A类：
Phenols,ciations,isoPGF2,mercapturic
B类：
Urinary,concentrations,phenols,oxidative,stress,biomarkers,thyroid,cancer,Exploring,associations,mediation,effects,have,been,shown,influence,cellular,proliferation,function,experimental,models,However,few,human,studies,investigated,underlying,mechanisms,are,also,poorly,understood,We,conducted,case,study,by,age,sex,matching,controls,between,exposures,risk,further,explore,mediating,role,found,that,elevated,urinary,triclosan,TCS,bisphenol,BPA,BPS,levels,were,increased,all,trends,adjusted,odds,ratios,ORs,comparing,extreme,groups,confidence,interval,respectively,Positive,observed,three,measured,hydroxy,deoxyguanosine,OHdG,prostaglandin,nonenal,acid,HNE,MA,well,Mediation,analysis,showed,mediated,Our,results,suggest,may,associated,lipid,peroxidation,intermediate,Further,warranted,confirm,findings
AB值：
0.46488
相似文献
机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
