典型文献
Protective role of electrophile-reactive glutathione for DNA damage repair inhibitory effect of dibromoacetonitrile
文献摘要：
Dibromoacetonitrile(DBAN)is a disinfection byproduct(DBP)and linked with cancer in ro-dents,but the mechanism of its carcinogenicity has not been fully elucidated.We recently reported that DBAN induced inhibition of nucleotide excision repair(NER).In this study,we investigated if glutathione(GSH)is involved in the DBAN-induced inhibition of NER.Human keratinocytes HaCaT were pretreated with L-buthionine-(S,R)-sulfoximine(BSO)to deplete intracellular GSH.BSO treatment markedly potentiated the DBAN-induced NER inhibition as well as intracellular oxidation.The recruitment of NER proteins(transcription factor IIH,and xeroderma pigmentosum complementation group G)to DNA damage sites was inhibited by DBAN,which was further exacerbated by BSO treatment.Our results suggest that intracellu-lar GSH protects cells from DBAN-induced genotoxicity including inhibition of DNA damage repair.
文献关键词：
中图分类号：
作者姓名：
Yukako Komaki;Koki Suganuma;Yuko Ibuki
作者机构：
Graduate Division of Nutritional and Environmental Sciences,University of Shizuoka,Shizuoka 422-8526,Japan
文献出处：
引用格式：
[1]Yukako Komaki;Koki Suganuma;Yuko Ibuki-.Protective role of electrophile-reactive glutathione for DNA damage repair inhibitory effect of dibromoacetonitrile)[J].环境科学学报（英文版）,2022(07):305-314
A类：
dibromoacetonitrile,Dibromoacetonitrile,DBAN,carcinogenicity,buthionine,intracellu,genotoxicity
B类：
Protective,role,electrophile,reactive,glutathione,damage,repair,inhibitory,effect,disinfection,byproduct,DBP,linked,cancer,dents,mechanism,its,has,been,fully,elucidated,We,recently,reported,that,induced,inhibition,nucleotide,excision,NER,In,this,study,investigated,if,GSH,involved,Human,keratinocytes,HaCaT,were,pretreated,sulfoximine,BSO,deplete,intracellular,treatment,markedly,potentiated,well,oxidation,recruitment,proteins,transcription,IIH,xeroderma,pigmentosum,complementation,group,sites,was,inhibited,which,further,exacerbated,Our,results,suggest,protects,cells,from,including
AB值：
0.537642
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