Disinfection by-products(DBPs),formed from the reactions of disinfectants with natural or-ganic matter and halides in drinking water,were considered to be cytotoxic and genotoxic,and might trigger various cancers.The relatively low concentration of DBPs in finished wa-ter(low μg/L or even ng/L levels)and the interference from water matrix inhibited in situ determination of DBPs.Moreover,the further formation and degradation of DBPs by disin-fectants during the holding time(several hours to several days)from sample collection to analysis could adversely affect the determination of DBPs.To obtain accurate,precise and reliable data of DBP occurrence and formation,robust and reliable sample preservation is indispensable.However,the commonly used quenching agents(e.g.,sodium sulfite,sodium thiosulfate,and ascorbic acid)for sample preservation can decompose reactive DBPs by re-ductive dehalogenation.This study evaluated the performance of N-acetylcysteine(NAC)and glutathione(GSH)as quenching agents for the analysis of halogenated DBPs by inves-tigating the stoichiometry of the disinfectant-quenching agent reaction,the formation of DBPs during chlor(am)ination of NAC or GSH,and the effects of NAC or GSH on the stability of 18 individual DBPs and total organic halogen(TOX).Based on the results of this study,NAC and GSH were considered to be ideal quenching agents for the analysis of most DBPs and TOX,except halonitromethanes.

Shunke Ding;Menglin Wu;Rong Xiao;Chao Fang;Qi Wang;Bin Xu;Wenhai Chu

State Key Laboratory of Pollution Control and Resource Reuse,College of Environmental Science and Engineering,Tongji University,Shanghai 200092,China;Key Laboratory of Yangtze River Water Environment,Ministry of Education,Tongji University,Shanghai 200092,China;School of Life and Environmental Science,Wenzhou University,Zhejiang 325035,China

环境科学学报（英文版）

[1]Shunke Ding;Menglin Wu;Rong Xiao;Chao Fang;Qi Wang;Bin Xu;Wenhai Chu-.Evaluation of N-acetylcysteine and glutathione as quenching agents for the analysis of halogenated disinfection by-products)[J].环境科学学报（英文版）,2022(07):71-79

fectants,thiosulfate,halonitromethanes

Evaluation,acetylcysteine,glutathione,quenching,agents,analysis,halogenated,disinfection,by,products,Disinfection,DBPs,formed,from,reactions,disinfectants,natural,matter,halides,drinking,water,were,considered,be,cytotoxic,genotoxic,might,trigger,various,cancers,relatively,low,concentration,finished,even,levels,interference,matrix,inhibited,situ,determination,Moreover,further,formation,degradation,during,holding,several,hours,days,sample,collection,could,adversely,affect,To,obtain,accurate,precise,reliable,data,occurrence,robust,preservation,indispensable,However,commonly,used,sodium,sulfite,ascorbic,acid,decompose,reactive,ductive,dehalogenation,This,study,evaluated,performance,NAC,GSH,inves,tigating,stoichiometry,chlor,effects,stability,individual,total,organic,TOX,Based,results,this,ideal,most,except

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