典型文献
Preparation and MRI performances of core-shell structural PEG salicylic acid-gadolinium composite nanoparticles
文献摘要:
Gadolinium(Ⅲ)-based T1 contrast agents have been widely used in clinical MRI.In this study,salicylic acid-gadolinium chelate was prepared via directly coordination reaction of gadolinium ion and salicylic acid.Then,three polyethylene glycols with different molecular weight were modified on the surface of salicylic acid-gadolinium by simple chemical coupling to construct three core-shell structural Gd based composites.The scanning electron microscopy(SEM)and transmission electron microscopy(TEM)characterization results show that the composite is a spherical particle with a diameter of about 100-200 nm.The longitudinal relaxation rate r1 of the Gal-PEG-2000 is 11.097(mmol/L)-1/s,and the ratio of r2/r1 is as low as 2.53.The composite shows good liver and intestines MRI performances after being used in in vivo imaging,showing a good prospect of biological application.
文献关键词:
中图分类号:
作者姓名:
Jia Zhang;Zhiyan Lin;Minzhi Zhao;Weibing Xu;Fang Nian
作者机构:
College of Science,Gansu Agricultural University,Lanzhou 730000,China;Clinical Medical College,Gansu University of Chinese Medicine,Lanzhou 730000,China
文献出处:
引用格式:
[1]Jia Zhang;Zhiyan Lin;Minzhi Zhao;Weibing Xu;Fang Nian-.Preparation and MRI performances of core-shell structural PEG salicylic acid-gadolinium composite nanoparticles)[J].稀土学报(英文版),2022(07):1098-1105
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B类:
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AB值:
0.608051
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