Nanotechnology has revolutionized cancer drug delivery,and recent research continues to focus on the devel-opment of"one-size-fits-alll,"i.e.,"all-in-one"delivery nanovehicles.Although nanomedicines can address sig-nificant shortcomings of conventional therapy,biological barriers remain a challenge in their delivery and accumulation at diseased sites.To achieve long circulation time,immune evasion,and targeted accumulation,conventional nanocarriers need modifications,e.g.,PEGylation,peptide/aptamer attachment,etc.One such modification is a biomimetic coating using cell membrane(CM),which can offer long circulation or targeting,or both.This top-down CM coating process is facile and can provide some advantageous features over surface modification by synthetic polymers.Herein,an overview is provided on the engineering of CM camouflaged polymer nanoparticles.A short section on CM and the development of CM coating technology has been provided.Detailed description of the preparation and characterization of CM camouflaged polymer NPs and their appli-cations in cancer treatment has been reported.A brief comparison between CM coating and PEGylation has been highlighted.Various targeting approaches to achieve tumor-specific delivery of CM coated NPs have been sum-marized here.Overall,this review will give the readers a nice picture of CM coated polymer NPs,along with their opportunities and challenges.

Kai Guo;Nanyang Xiao;Yixuan Liu;Zhenming Wang;Judit Tóth;János Gyenis;Vijay Kumar Thakur;Ayako Oyane;Quazi T.H.Shubhra

Stomatology Hospital of Guangzhou Medical University,Guangzhou Medical University,Guangzhou,510140,China;Department of Microbiology,The University of Chicago,Chicago,IL,60637,USA;Department of Pathology,School of Basic Medical Sciences,Nanjing Medical University,Nanjing,21116,China;State Key Laboratory of Oral Diseases,West China Hospital of Stomatology,Sichuan University,Chengdu,610041,China;Research Centre for Natural Sciences,Institute of Materials and Environmental Chemistry,1117,Budapest,Magyar Tudósok K?rútja 2,Hungary;University of Pannonia,Egyetem u.10,H-8200,Veszprém,Hungary;School of Engineering,University of Petroleum&Energy Studies(UPES),Dehradun 248007,India;Nanomaterials Research Institute,National Institute of Advanced Industrial Science and Technology(AIST),Tsukuba,305-8565,Japan

纳米材料科学（英文版）

[1]Kai Guo;Nanyang Xiao;Yixuan Liu;Zhenming Wang;Judit Tóth;János Gyenis;Vijay Kumar Thakur;Ayako Oyane;Quazi T.H.Shubhra-.Engineering polymer nanoparticles using cell membrane coating technology and their application in cancer treatments:Opportunities and challenges)[J].纳米材料科学（英文版）,2022(04):295-321

alll,nanovehicles

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